Role of gut microbiome in regulating the effectiveness of metformin in reducing colorectal cancer in type 2 diabetes

doi:10.12998/wjcc.v8.i24.6213

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 8, Issue 24

This Article

(266)

(268)

(0)

(12)

(1)

(8617)

(18)

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Supplementary Materials of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Journal Information of This Article

Publication Name

World Journal of Clinical Cases

ISSN

2307-8960

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

- Full Article with Cover (PDF)
- Full Article (XML)

Minireviews

World J Clin Cases. Dec 26, 2020; 8(24): 6213-6228
Published online Dec 26, 2020. doi: 10.12998/wjcc.v8.i24.6213

Table 1 Summary of the alteration of gut microbiota in patients with colorectal cancer from 2014 to 2019

Tumor types	Status	Alteration of gut microbiota
Adenomas	Increased¹	Families: Ruminococcaceae, Porphyromonadaceae
		Genera: Clostridium, Pseudomonas
		Species: Fusobacterium nucleatum, Atopobium parvulum, Actinomyces odontolyticus
	Decreased¹	Order: Clostridiales
		Family: Lachnospiraceae
		Genera: Bacteroides, Clostridium
		Species: Bifidobactium animalis, Streptococcus thermophilus
Carcinoma	Increased¹	Classes: Bacilli, Gammaproteobacteria
		Order: Enterobacteriales
		Genera: Bacteroides, Parabacteroides, Fusobacterium, Alistipes, Escherichia, Parvimonas, Bilophila. Porphyromonas, Actinomyces, Streptococcus
		Species: Alistipes putredinis, Bilophila wadsworthia, Lachnospiraceae bacterium, Enterobacteriaceae. Fusobacterium nucleatum spp., Actinomyces odontolyticus, Atopobium parvulum
	Decreased¹	Classes: Erysipelotrichi, Clostridia
		Order: Clostridiales
		Families: Lachnospiraceae, Ruminococcaceae, Clostridiaceae
		Genera: Bacteroides
		Species: Bifidobactium animalis, Streptococcus thermophilus
CRC	Increased¹	Phyla: Firmicutes, Fusobacteria, Bacteroidetes
		Families: Erysipelotrichaceae, Prevotellaceae, Coriobacteriaceae
		Genus: Peptostreptococcus
		Species: Colinsella aerofaciens, Dorea longicatena, Porphyromonas uenonis, Selenomonas sputigena, Streptococcus anginosus, Desulfovibrio vietnamensis, Bilophila wadsworthia, Fusobacterium nucleatum, Parvimonas micra, Peptostreptococcus anaerobius, Solobacterium moorei, Eubacterium ventriosum, Clostridium hathewayi, Bacteroides clarus, Roseburia intestinalis
		Others: clbA+ bacteria, Clostridium symbiosum
	Decreased¹	Genus: Bifidobacterium
		Species: Lachnospira multipara, Eubacterium eligens

¹Compared with healthy subjects. A simultaneous increase or decrease of a certain bacteria in the same stage of colorectal cancer means that the current research on this bacteria is still controversial. CRC: Colorectal cancer.

Full Size Table

Citation: Huang QY, Yao F, Zhou CR, Huang XY, Wang Q, Long H, Wu QM. Role of gut microbiome in regulating the effectiveness of metformin in reducing colorectal cancer in type 2 diabetes. World J Clin Cases 2020; 8(24): 6213-6228
URL: https://www.wjgnet.com/2307-8960/full/v8/i24/6213.htm
DOI: https://dx.doi.org/10.12998/wjcc.v8.i24.6213

Huang QY, Yao F, Zhou CR, Huang XY, Wang Q, Long H, Wu QM. Role of gut microbiome in regulating the effectiveness of metformin in reducing colorectal cancer in type 2 diabetes. World J Clin Cases 2020; 8(24): 6213-6228 [PMID: 33392303 DOI: 10.12998/wjcc.v8.i24.6213]

All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.