Copyright
©The Author(s) 2020.
World J Clin Cases. Aug 6, 2020; 8(15): 3218-3229
Published online Aug 6, 2020. doi: 10.12998/wjcc.v8.i15.3218
Published online Aug 6, 2020. doi: 10.12998/wjcc.v8.i15.3218
Table 3 The effect of thalidomide treatment on refractory gastrointestinal bleeding due to vascular malformation
| Patient | Duration of treatment (mo) | Recurrence of bleeding after 6 mo | Number of hospitalizations due to GIB | Units RBC transfused | Number of endoscopic treatments (APC) | Comments | |||
| 1 yr before thalidomide | After starting thalidomide | 1 yr before thalidomide | After starting thalidomide | 1 yr before thalidomide | After starting thalidomide | ||||
| 1 | 6 | No | 2 | 0 | 21 | 0 | 2 | 0 | |
| 2 | 19 | Yes | 4 | 1 | 8 | 12 | 3 | 1 | Side effect of fatigue and dizziness |
| 3 | 45 | No | 2 | 0 | 20 | 0 | 1 | 0 | Side effect of neuropathy |
| 4 | 14 | No | 1 | 0 | Weekly transfusion | 0 | 6 | 0 | Side effect of fatigue and constipation. Death |
| 5 | 44 | Yes | 5 | 1 | 14 | 4 | 4 | 1 | Side effect of neuropathy. Death, Sepsis |
| 6 | 17 | Yes | 6 | 5 | Biweekly transfusion | 4 | 3 | 2 | Stopped due to cost. Death |
| 7 | 24 | Yes | 9 | 3 | 33 | 9 | 4 | 10 | Death |
| 8 | 30 | Yes | 1 | 2 | 2 | 8 | 2 | 1 | Side effect of fatigue |
| 9 | 28 | Yes | 17 | 8 | 48 | 32 | 12 | 1 | Death |
| 10 | 3 | NA | 1 | 0 | 3 | 0 | 1 | 0 | Stopped due to drug interaction |
| 11 | 25 | No | 20 | 1 | 65 | 3 | 12 | 1 | Death, Sepsis |
| 12 | 6 | No | 2 | 0 | 99 | 0 | 9 | 4 | Side effect of neutropenia |
| 13 | 3 | NA | 1 | 1 | 12 | 16 | 1 | 1 | |
- Citation: Bayudan AM, Chen CH. Thalidomide for refractory gastrointestinal bleeding from vascular malformations in patients with significant comorbidities. World J Clin Cases 2020; 8(15): 3218-3229
- URL: https://www.wjgnet.com/2307-8960/full/v8/i15/3218.htm
- DOI: https://dx.doi.org/10.12998/wjcc.v8.i15.3218