Gastric pyloric gland adenoma resembling a submucosal tumor: A case report

Figure 2 Histopathological and immunohistochemical findings of the pyloric gland adenoma. A-C: Hematoxylin and eosin staining. The submucosal layer shows presence of nodular-like lesions with clear boundaries and increasing number of glands in the lamina propria of the orifice (white arrow) (A; magnification: × 20). Some glandular cavity was irregular, with cystic expansion (orange arrow) and interstitial edema (B; magnification: × 200). The cuboidal or low columnar epithelial cells line the mucus-rich tubular glands in these lesions (C; magnification: × 200); D-F: Immunohistochemical staining. The glandular epithelial cells revealed strongly positive for mucin mucin 6 (D) and mucin 5AC (E) and sparsely positive for Ki67 (F). Magnification: D-F: × 100. MUC5AC: Mucin 5AC; MUC 6: Mucin 6.