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©The Author(s) 2020.
World J Clin Cases. Jun 6, 2020; 8(11): 2092-2101
Published online Jun 6, 2020. doi: 10.12998/wjcc.v8.i11.2092
Published online Jun 6, 2020. doi: 10.12998/wjcc.v8.i11.2092
Table 2 Clinical course of the cases
| Case (number) | Type of apheresis | Ulcer before the treatment | Number of therapies | CRP mg / dL (before, after) | WBC / μL (before, after) | Neutrophils % (before, after) | Clinical courses | Side effect | Relapse (follow up) |
| 1 | GCAP | NA | 10 | 19.9, 0.6 | 17900, 4700 | NA | Ulcer was fully re-epithelialized after 10 weeks | NA | NA |
| 2 | GCAP | NA | 5 | 2.91, negative | NA | NA | Complete healing after 5th treatment | Mild headache | Yes (5 mo) |
| 3 | GCAP | NA | 5 | NA | NA | NA | Improve after 5th treatment | NA | NA |
| 4 | GCAP | NA | NA | NA | NA | NA | Symptoms were relieved with frequent GCAP and granulo-cytopenic therapy | NA | - |
| 5 | GCAP | NA | 5 | NA | NA | NA | Complete healing after 5th treatment | NA | - |
| 6 | GCAP | 9 cm | 10 | NA | NA | NA | Pain relieved 2nd treatment; ulcers were re-epithelialized after 4th treatment | None | - |
| 7 | GCAP | NA | 10 | 7.1, negative | NA | NA | Ulcer was fully re-epithelialized after 9th treatment | NA | - |
| 8 | GCAP | NA | NA | NA | NA | NA | Complete healing after the treatment | NA | - |
| 9 | GCAP | NA | 11 | NA | NA | NA | Ulcer was fully re-epithelialized one month after the 1st treatment | NA | - |
| 10 | GCAP | NA | 5 | NA | NA | NA | Ulcer improved partly but remained | NA | Yes (2 mo) |
| 11 | GCAP | 7 cm | 5 | 13.71, 0.21 | NA | NA | Ulcer improved after 5th treatment | None | No (6 mo) |
| 12 | GCAP | 6.5 cm | 10 | NA | NA | NA | Ulcer was fully re-epithelialized 3 month after the 10th treatment | NA | Yes (6 mo) |
| 13 | GCAP | NA | 10 | 12.1, negative | NA | NA | Ulcer was fully re-epithelialized after the 10th treatment | NA | - |
| 14 | GCAP | NA | 5 | NA | NA | NA | Ulcer improved 2 months after the 5th treatment | NA | 2 times (1 mo, 2 mo) |
| 15 | GCAP | NA | 10 | 6.53, negative | NA | NA | Ulcer and symptoms improved after 3rd treatment | None | - |
| 16 | GCAP | 3.1 cm | 10 | NA | NA | NA | Ulcer was fully re-epithelialized 2 months after the 1st treatment | None | No (2 yr) |
| 17 | GCAP | NA | 10 | 4.73, negative | NA | NA | Ulcer was fully re-epithelialized after the 10th treatment | NA | - |
| 18 | GCAP | 7 cm | 10 | 0.45, 0.04 | 12310, 7490 | 74.9, 89.0 | Ulcer was partly re-epithelialized after the 10th treatment | None | No (4 yr) |
| 19 | LCAP | NA | 5 | 7.76, negative | NA | NA | Ulcer was partly re-epithelialized after the 3rd treatment | NA | - |
| 20 | LCAP | NA | 5 | 1.3, 0.3 | 10400, 6400 | 88, 60 | Ulcer was fully re-epithelialized after the 3rd treatment | None | No (4 mo) |
| 21 | LCAP | 4 cm | 4 | 6.6, 0.1 | 10800, 9100 | 84, 90 | Skin lesion improved 3 months after the 4th treatment | NA | - |
| 22 | LCAP | 7 cm | 10 | 4.7, 1.3 | 11900, 7140 | NA | Ulcer was fully re-epithelialized after the first round of LCAP, recurred with the tapering of PSL during the 2nd period of LCAP. | NA | No (2 yr) |
| 23 | LCAP | NA | 10 | 22.46, negative | NA | NA | Ulcer and symptoms improved after 10th treatment | NA | No |
- Citation: Tominaga K, Kamimura K, Sato H, Ko M, Kawata Y, Mizusawa T, Yokoyama J, Terai S. Cytapheresis for pyoderma gangrenosum associated with inflammatory bowel disease: A review of current status. World J Clin Cases 2020; 8(11): 2092-2101
- URL: https://www.wjgnet.com/2307-8960/full/v8/i11/2092.htm
- DOI: https://dx.doi.org/10.12998/wjcc.v8.i11.2092