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Publication Name
World Journal of Clinical Cases
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2307-8960
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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©The Author(s) 2019.
World J Clin Cases. Nov 6, 2019; 7(21): 3486-3504
Published online Nov 6, 2019. doi: 10.12998/wjcc.v7.i21.3486
Table 3 Strengths of recommendations regarding pharmacological interventions for functional constipation in 14 clinical practice guidelines
CategoryDrugsRecommendations by CPGs
Bulking agentsPsylliumStrongly recommended or recommended by 10 CPGs
BranRecommended by 2 CPGs, insufficient evidence reported by 6 CPGs
Stool softenersDocusate sodiumInsufficient evidence reported by 4 CPGs
Liquid paraffinInsufficient evidence reported by 4 CPGs
GlycerinInsufficient evidence reported by 4 CPGs
Osmotic laxativesPEGStrongly recommended or recommended by 10 CPGs
LactuloseRecommended by 10 CPGs
Magnesium saltsRecommended by 1 CPG, insufficient evidence reported by 2 CPGs
Stimulant laxativesBisacodylRecommended by 9 CPGs, weak evidence reported by 1 CPG, insufficient evidence reported by 1 CPG
Sodium picosulfateRecommended by 9 CPGs, weak evidence reported by 1 CPG, insufficient evidence reported by 1 CPG
SennaInsufficient evidence reported by 6 CPGs
Prosecretory agentsLubiprostoneStrongly recommended or recommended by 7 CPGs
LinaclotideStrongly recommended or recommended by 7 CPGs
OthersPrucaloprideStrongly recommended or recommended by 9 CPGs
ProbioticsInsufficient evidence reported by 6 CPGs
Enema and suppositoriesWeak evidence reported by 6 CPGs, Strongly recommended by 1 CPG (CO2-releasing suppositories for distal constipation)
PEG: Polyethylene glycol; CPG: Clinical practice guidelines.
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