Association of stiff-person syndrome with autoimmune endocrine diseases

Table 2 Autoimmune diseases and autoantibodies associated with stiff-person syndrome

Variable	Classical SPS	SLS
Number of patients (n)	12	2
Associated disease
≥2 coexisting autoimmune diseases (n)	1	0
Type 1 diabetes mellitus (n)	2	0
Latent autoimmune diabetes in adults (n)	1	0
Autoimmune thyroid disease (n)	2	0
Sjögren syndrome (n)	1	0
Myasthenia graves (n)	1	0
Malignancy1 (n)	1	0
Thymoma (n)	1	0
Other disease (n)	12	nil
Associated autoantibody (n/N)3
GAD antibody	3/7	0/2
IA-2 antibody	0/2	nil
Anti-TPO	2/5	nil
ATA	1/1	nil
Ach-R antibody	1/1	nil
ANA	1/1	nil
Anti-Ro antibody	1/1	nil

¹One patient had lung cancer.

²One patient had type 2 diabetes mellitus.

³Number of patients positive for the associated antibody/number of patients tested for the associated antibody. SPS: Stiff-person syndrome; SLS: Stiff limb syndrome; GAD: Glutamic acid decarboxylase; IA-2: Islet antigen 2; TPO: Thyroid peroxidase; ATA: Anti-thyroglobulin antibody; AchR: Acetylcholine receptor; ANA: Anti-nuclear antibody.