Anti-hepatitis C virus therapy in chronic kidney disease patients improves long-term renal and patient survivals

Table 3 Crude and adjusted hazard ratios for end-stage renal disease

Variable	Crude			Adjusted1
	HR	95%CI	P value	HR	95%CI	P value
CKD patients
Uninfected	1.00	Reference		1.00	Reference
Treated	0.31	0.13-0.77	0.011	0.34	0.14-0.84	0.019
Untreated	1.25	1.00-1.56	0.046	1.28	1.03-1.60	0.029
Sex, men/women	1.11	0.89-1.38	0.35	1.23	0.99-1.55	0.07
Age, per year	1.01	1.00-1.01	0.15	0.99	0.98-0.99	0.006
Comorbidity, yes/no
Diabetes	2.87	2.28-3.61	< 0.001	3.06	2.37-3.95	< 0.001
Hypertension	3.08	2.37-4.01	< 0.001	3.51	2.57-4.79	< 0.001
Coronary heart disease	1.28	1.02-1.59	0.031	0.92	0.72-1.16	0.46
Hyperlipidemia	1.29	1.04-1.60	0.023	0.85	0.68-1.07	0.16
Cirrhosis	0.62	0.46-0.83	0.001	0.61	0.44-0.84	0.003
ACEI/ARB, yes/no	1.38	0.65-2.92	0.40	0.96	0.46-2.04	0.92
Enrollee category
1	1.00	Reference		1.00	Reference
2	0.68	0.21-2.14)	0.50	0.56	0.17-1.80	0.33
3	1.26	0.97-1.64	0.08	1.24	0.95-1.63	0.11
4	1.47	1.09-1.99	0.012	1.40	1.03-1.92	0.03
Number of medical visits	1.00	1.00-1.01	0.36	1.00	0.99-1.00	0.41
Charlson comorbidity index score	1.01	00.98-1.04	0.46	0.93	0.89-0.98	0.008

¹Adjusted for all covariates (age per year, sex, comorbidity, ACEI/ARB, enrollee category, number of medical visits, and Charlson comorbidity index score) and competing mortality. CKD: Chronic kidney disease; ACEI/ARB: Angiotensin converting enzyme inhibitor/angiotensin receptor blocker; CI: Confidence interval.