Must Peutz-Jeghers syndrome patients have the LKB1/STK11 gene mutation? A case report and review of the literature

Figure 10 Repairing single-base mismatch in S phase by MutSα[30]. 1: A mismatch appears in the daughter strand; 2: Upon encountering the mispair, the MutSα, which consists of hMSH2, hMSH6 and ADP, switches to a closed, sliding clamp along the DNA. This process is accompanied by exchanging of ATP for ADP; 3: Multiple MutSα clamps may be recruited to the mismatch. Moving in the 5′ > 3′ direction, the MutSα will meet and displace the PCNA-DNA polymerase complex in DNA synthesis; 4: Exonuclease I excises the nucleotides of the daughter strand back to the site of the mismatch; 5: The daughter strand is resynthesized and the error is corrected.