Successful rescue of acute liver failure and hemophagocytic lymphohistiocytosis following varicella infection: A case report and review of literature

Figure 2 Curves of evolving laboratory values. A, B: On May 21, the patient had a normal white blood cell count (WBC), hemoglobin (Hb), and Plt count before disease onset. On May 31, he had thrombopenia, 4 d after the onset of the skin rash. Sudden and unexpected pancytopenia occurred on June 4. Two doses of dexamethasone (20 mg) and etoposide (150 mg/m²) were administered on June 5, and June 8, respectively. Granulocyte colony stimulating factor was used to treat etoposide-induced agranulocytosis from June 13 to June 15. The WBC, hemoglobin and Plts eventually returned to normal; C: The alanine aminotransferase (ALT) and aspartate aminotransferase (AST) soared on June 1st, though intravenous acyclovir had been started at a dose of 10 mg/kg/d from May 31 to June 2. Then acyclovir was increased to 10 mg/kg every 8 h (June 3 to June 12). The liver enzymes reached a maximum (ALT 6499 U/L, AST 9458 U/L) on June 3 and then declined quickly; D: The T-Bil rose gradually, reaching a maximum of 59 μmol/L on June 8. Total bilirubin (T-Bil) continued to improve thereafter. Alb declined concurrent with the progression of ALF, and was elevated with multiple infusions of albumin; E: Prothrombin activity (PTA) was reduced to 45% when ALF occurred, and was partially ameliorated by infusions of fresh-frozen plasma. Fib decreased markedly, with a lowest level of 102 mg/dL, despite multiple infusions of fib. After a second dose of dexamethasone and etoposide on June 8, fib started to improve steadily. F: An extremely high level of serum ferritin was noted to accompany the onset of pancytopenia. It dropped dramatically once treatment had taken effect. WBC: White blood cell count; Hb: Hemoglobin; Plt: Platelet; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; T-Bil: Total bilirubin; Alb: Albumin; ALF: Acute liver failure; PTA: Prothrombin activity; Fib: Fibrinogen.