Impact of an acute hemodynamic response-guided protocol for primary prophylaxis of variceal bleeding

Table 5 Results of univariate analysis for variables associated with risk of death

Variables	Univariable
	HR (95%CI)	P value
Age as per year increase	1.01 (0.93-1.09)	0.896
Active alcoholism	0.04 (0.00-2577625.31)	0.731
Size of varices	0.28 (0.03-2.55)	0.259
MELD as per 1 point increase	0.91 (0.72-1.16)	0.448
Child score as per 1 point increase	0.98 (0.59-1.67)	0.941
Platelets as per 1 × 106	0.98 (0.95-1.00)	0.088
Creatinine as per 1 mg/dL increase	0.01 (0.00-4.55)	0.134
Bilirubin as per 1 mg/dL increase	0.90 (0.59-1.39)	0.642
Albumin as per 1 g/L increase	0.65 (0.17-2.43)	0.521
INR as per 1 point increase	0.06 (0.00-4.39)	0.196
HVGP as per 1 mmHg increase	1.12 (0.94-1.33)	0.195
MAP as per 1 mmHg increase	1.01 (0.93-1.10)	0.791
Previous ascites	1.73 (0.34-8.96)	0.511
Previous hepatocellular carcinoma	3.41 (0.40-29.45)	0.264
Previous hepatic encephalopathy	2.72 (0.53-14.08)	0.233
No previous decompensation	0.58 (0.11-3.01)	0.518
Acute hemodynamic response	2.99 (0.36-24.91)	0.312
Chronic hemodynamic response-10%	0.23 (0.02-2.57)	0.234
Chronic hemodynamic response-20%	0.02 (0.00-427.79)	0.455

BMI: Body mass index; HVPG: Hepatic venous gradient pressure; INR: International normalized ratio; MAP: Mean arterial pressure; SBP: Spontaneous bacterial peritonitis.