Low expression of angiotensinogen and dipeptidyl peptidase 1 in saliva of patients with proliferative verrucous leukoplakia

Table 3 Average of spectral counts, standard deviation, P value and fold-change of 31 proteins with difference in the abundance levels in proliferative verrucous leukoplakia saliva compared to the control group according to ANOVA test

Accession number	Protein (31)	Control		PVL		P value	FC
		SC	SD	SC	SD
sp|P58876|H2B1D_HUMAN	Histone H2B type 1-D	0.12	0.32	1.09	1.73	0.0413	9.08
sp|P04264|K2C1_HUMAN	Keratin, type II cytoskeletal 1	2.33	2.45	5.24	4.67	0.0418	2.24
sp|P80748|LV302_HUMAN	Ig lambda chain V-III region LOI	0.45	0.50	1.01	0.66	0.0154	2.24
sp|P31025|LCN1_HUMAN	Lipocalin-1	7.03	4.46	13.44	6.84	0.005a	1.91
sp|P04080|CYTB_HUMAN	Cystatin-B	1.67	1.38	3.19	2.25	0.0338	1.91
sp|Q01469|FABP5_HUMAN	Fatty acid-binding protein, epidermal	2.22	1.36	3.99	2.04	0.009a	1.79
sp|P68032|ACTC_HUMAN	Actin, alpha cardiac muscle 1	9.66	3.79	6.78	3.71	0.0446	-1.42
sp|P02814|SMR3B_HUMAN	Submaxillary gland androgen-regulated protein 3B	18.26	9.40	11.05	5.19	0.0148	-1.66
sp|P06744|G6PI_HUMAN	Glucose-6-phosphate isomerase	4.21	2.89	2.12	2.05	0.0309	-2.00
sp|P30740|ILEU_HUMAN	Leukocyte elastase inhibitor	3.93	1.57	1.87	1.75	0.002a	-2.12
sp|Q06830|PRDX1_HUMAN	Peroxiredoxin-1	2.11	1.41	0.87	1.04	0.0106	-2.43
sp|P62328|TYB4_HUMAN	Thymosin beta-4	1.09	1.01	0.40	0.64	0.0323	-2.77
sp|Q96HE7|ERO1A_HUMAN	ERO1-like protein alpha	0.93	0.67	0.32	0.59	0.0126	-2.94
sp|P23528|COF1_HUMAN (+1)	Cofilin-1	1.66	1.79	0.54	0.99	0.0423	-3.12
sp|Q02818|NUCB1_HUMAN	Nucleobindin-1	0.82	0.56	0.27	0.47	0.007a	-3.12
sp|P52566|GDIR2_HUMAN	Rho GDP-dissociation inhibitor 2	1.61	1.76	0.49	0.79	0.0317	-3.33
sp|Q01518|CAP1_HUMAN	Adenylyl cyclase-associated protein 1	3.18	2.86	0.83	0.97	0.005a	-3.84
sp|P26038|MOES_HUMAN	Moesin	2.44	2.52	0.60	0.63	0.0107	-4.16
sp|P61586|RHOA_HUMAN	Transforming protein RhoA	0.53	0.63	0.13	0.36	0.0453	-4.16
sp|P27797|CALR_HUMAN	Calreticulin	0.61	0.65	0.13	0.35	0.0172	-4.76
sp|P06737-2|PYGL_HUMAN (+1)	Isoform 2 of Glycogen phosphorylase, liver form	1.70	2.11	0.34	0.63	0.0239	-5.00
sp|P61158|ARP3_HUMAN	Actin-related protein 3	0.97	1.33	0.13	0.35	0.0268	-7.69
sp|P43490|NAMPT_HUMAN	Nicotinamide phosphoribosyl transferase	0.53	0.64	0.07	0.26	0.0139	-7.69
tr|A6NNY3|A6NNY3_HUMAN	Chitinase-3-like protein 2	0.61	0.75	0.07	0.28	0.0143	-9.09
sp|P30041|PRDX6_HUMAN	Peroxiredoxin-6	0.60	0.87	0.05	0.21	0.0255	-12.5
sp|P01019|ANGT_HUMAN	Angiotensinogen	0.83	0.73	0.07	0.26	0.0006a	-12.5
sp|P0C0L5|CO4B_HUMAN	Complement C4-B	0.93	1.02	0.07	0.28	0.004a	-14.28
sp|P53634|CATC_HUMAN	Dipeptidyl peptidase 1	0.66	0.98	0.00	0.00	0.015	NC
sp|P22392-2|NDKB_HUMAN (+1)	Isoform 3 of Nucleoside diphosphate kinase B	0.58	0.60	0.00	0.00	0.000a	NC
sp|P22314|UBA1_HUMAN	Ubiquitin-like modifier-activating enzyme 1	0.38	0.59	0.00	0.00	0.0189	NC
sp|Q9UHA7|IL36A_HUMAN	Interleukin-36 alpha	0.43	0.68	0.00	0.00	0.0197	NC

FC: Fold-change; Up-regulation: FC ≥ +1.00; Down-regulation: FC < +1.00;

^aP≤ 0.01 vs control; NC: Not calculated; SC: Spectral counts; SD: Standard deviation.