Combination of N-methyl-D-aspartate receptor antagonists and propofol for procedural sedation

doi:10.12998/wjcc.v14.i8.118582

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Meta-Analysis

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Cases. Mar 16, 2026; 14(8): 118582
Published online Mar 16, 2026. doi: 10.12998/wjcc.v14.i8.118582

Table 4 Summary of meta-regression findings for hypotension outcome, showing direction and approximate trend of associations between covariates (propofol dosage, mean age, and ketamine dosage) and log risk ratio

Covariate (moderator)	Direction of association	Approximate trend
Propofol dosage difference (msg)	Positive	Each 50 mg increase in propofol appeared to increase LogRR by approximately 0.05-0.10
Mean age (years)	Slighty negative	Each approximately 10 years increase in mean age appeared to decrease LogRR by approximately 0.01 (very weak)
Ketamine dosage difference	Negative	Each 50 mg increase in ketamine appeared to decrease LogRR by approximately 0.05-0.08

LogRR: Log risk ratio.

Full Size Table

Citation: Faheem MSB, Hassan ST, Feroze F, Khan A, Munir SU, Khaliq A, Fatima ST, Mendonca R, Surani S. Combination of N-methyl-D-aspartate receptor antagonists and propofol for procedural sedation. World J Clin Cases 2026; 14(8): 118582
URL: https://www.wjgnet.com/2307-8960/full/v14/i8/118582.htm
DOI: https://dx.doi.org/10.12998/wjcc.v14.i8.118582

Faheem MSB, Hassan ST, Feroze F, Khan A, Munir SU, Khaliq A, Fatima ST, Mendonca R, Surani S. Combination of N-methyl-D-aspartate receptor antagonists and propofol for procedural sedation. World J Clin Cases 2026; 14(8): 118582 [DOI: 10.12998/wjcc.v14.i8.118582]

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