Contrasting diagnostic challenges of headache before and after acute disseminated encephalomyelitis in children: Two case reports and review of literature

Figure 2 Comprehensive clinical and chronological timeline for case 2. Detailing the entire trajectory from initial acute disseminated encephalomyelitis presentation (day 0), acute treatment, the 3-month persistent headache and preventive medication window (days +14 to +90), readmission assessment (day +90), repeat corticosteroid course (days +93 to +95), subsequent headache resolution (approximately day +110), to final follow-up imaging (day +120). MRI: Magnetic resonance imaging; ADEM: Acute disseminated encephalomyelitis; CSF: Cerebrospinal fluid; MOG-IgG: Myelin oligodendrocyte glycoprotein immunoglobulin G; IVIG: Intravenous immunoglobulin; IVMP: Intravenous methylprednisolone; IV: Intravenous.