Acute liver failure temporally associated with intensive consumption of Plantago major tea: A case report

Figure 3 Histopathological examination of the explanted native liver. A: Low-power panoramic view showing extensive confluent areas of hepatic parenchymal necrosis with marked architectural distortion, interspersed with relatively preserved/regenerative parenchyma [hematoxylin and eosin (H&E), digital magnification 0.6×; scale bar = 2000 μm]; B: Intermediate-power view showing extensive hepatocellular necrosis with marked architectural disruption, regenerative changes, focal inflammatory cell aggregates, and bile plugs consistent with cholestasis (H&E, digital magnification 10.9×; scale bar = 100 μm); C: High-power view demonstrating regenerative hepatocellular changes with enlarged hepatocytes and nuclear variability, associated with prominent canalicular and intracellular bile pigment consistent with marked cholestasis (H&E, digital magnification 44.4×; scale bar = 20 μm); D: Reticulin stain demonstrating marked disruption and collapse of the reticulin framework in areas of severe parenchymal injury (digital magnification 8.0×; scale bar = 200 μm). These histopathological findings were nonspecific and did not establish the etiology of the acute liver injury.