Obesity and postoperative opioid utilization after total knee arthroplasty: A propensity-matched analysis

doi:10.12998/wjcc.125054

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Cases. Sep 6, 2026; 14(25): 125054
Published online Sep 6, 2026. doi: 10.12998/wjcc.125054

Table 1 Demographics and medical comorbidities for body mass index ≥ 40 vs body mass index < 30 cohorts before and after propensity score matching, n (%)/mean ± SD

	Before PSM				After PSM
	BMI ≥ 40 (n = 883)	BMI < 30 (n = 3835)	P value	SMD	BMI ≥ 40 (n = 807)	BMI < 30 (n = 807)	P value	SMD
Age	60.5 8.4	69.5 10.0	< 0.001	0.968	60.9 8.2	60.6 8.9	0.522	0.032
Race
White	612 (73.3)	2953 (80.9)	< 0.001	0.182	599 (74.2)	605 (75.0)	0.732	0.017
Black or African American	156 (18.7)	274 (7.5)	< 0.001	0.336	143 (17.7)	138 (17.1)	0.743	0.016
Asian	10 (1.2)	108 (3.0)	0.004	0.124	10 (1.2)	0 (0.0)	0.002	0.158
Native Hawaiian or Other Pacific Islander	0 (0.0)	10 (0.3)	0.130	0.074	0 (0.0)	0 (0.0)	> 0.999	< 0.001
American Indian or Alaska Native	10 (1.2)	10 (0.3)	< 0.001	0.108	10 (1.2)	10 (1.2)	> 0.999	< 0.001
Other race	10 (1.2)	63 (1.7)	0.276	0.044	10 (1.2)	10 (1.2)	> 0.999	< 0.001
Unknown race	54 (6.5)	243 (6.7)	0.842	0.008	53 (6.6)	54 (6.7)	0.920	0.005
Sex
Male	200 (24.0)	1418 (38.8)	< 0.001	0.325	198 (24.5)	210 (26.0)	0.492	0.034
Female	635 (76.0)	2231 (61.1)	< 0.001	0.326	609 (75.5)	597 (74.0)	0.492	0.034
Unknown	0 (0.0)	10 (0.3)	0.130	0.074	0 (0.0)	0 (0.0)	> 0.999	< 0.001
Medical comorbidities
Mood (affective) disorders	84 (10.1)	231 (6.3)	< 0.001	0.136	79 (9.8)	64 (7.9)	0.189	0.065
Anxiety disorders	66 (7.9)	246 (6.7)	0.233	0.045	62 (7.7)	51 (6.3)	0.283	0.053
Chronic pain syndrome	10 (1.2)	13 (0.4)	0.002	0.096	10 (1.2)	10 (1.2)	> 0.999	< 0.001
Chronic pain	79 (9.5)	259 (7.1)	0.020	0.086	75 (9.3)	70 (8.7)	0.663	0.022
Diabetes mellitus	140 (16.8)	462 (12.7)	0.002	0.116	135 (16.7)	114 (14.1)	0.148	0.072
Hyperlipidemia (unspecified)	146 (17.5)	861 (23.6)	< 0.001	0.152	144 (17.8)	111 (13.8)	0.024	0.112
Pure hypercholesterolemia	66 (7.9)	464 (12.7)	< 0.001	0.159	65 (8.1)	49 (6.1)	0.120	0.077
Essential (primary) hypertension	293 (35.1)	1366 (37.4)	0.207	0.049	280 (34.7)	220 (27.3)	0.001	0.161
CKD	17 (2.0)	126 (3.5)	0.036	0.087	17 (2.1)	12 (1.5)	0.349	0.047
Nicotine dependence	18 (2.2)	78 (2.1)	0.973	0.001	18 (2.2)	16 (2.0)	0.729	0.017
Coronary artery disease	45 (5.4)	314 (8.6)	0.002	0.126	43 (5.3)	39 (4.8)	0.650	0.023

BMI: Body mass index; CKD: Chronic kidney disease; PSM: Propensity score matching; SMD: Standardized mean difference.

Full Size Table

Citation: Wu KA, Mai E, Warburton CS, Dhanjani S, Choudhury A, Docters F, Wong L, Prabhat A, Raza M, Maayan O, Song J, Shatkin M, Moucha CS, Hayden BL. Obesity and postoperative opioid utilization after total knee arthroplasty: A propensity-matched analysis. World J Clin Cases 2026; 14(25): 125054
URL: https://www.wjgnet.com/2307-8960/full/v14/i25/125054.htm
DOI: https://dx.doi.org/10.12998/wjcc.125054

Wu KA, Mai E, Warburton CS, Dhanjani S, Choudhury A, Docters F, Wong L, Prabhat A, Raza M, Maayan O, Song J, Shatkin M, Moucha CS, Hayden BL. Obesity and postoperative opioid utilization after total knee arthroplasty: A propensity-matched analysis. World J Clin Cases 2026; 14(25): 125054 [DOI: 10.12998/wjcc.125054]

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