Extensive multiple calcinosis cutis in seronegative limited cutaneous scleroderma (CREST variant): A case report

doi:10.12998/wjcc.123670

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Case Report

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Cases. Sep 6, 2026; 14(25): 123670
Published online Sep 6, 2026. doi: 10.12998/wjcc.123670

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Figure 3 Excisional biopsy procedure. A: Careful dissection was performed between the thinned skin tissue and subcutaneous calcified tissue. B: The extracted calcified tissue. C: Permanent biopsy analysis under an optical microscope (200× magnification, hematoxylin and eosin stain) revealed aggregated lymphocytes and fibrosis around the massive calcification, suggestive of an autoimmune response.

Citation: Lee HY, Lee SK, Kim H, Kang SW. Extensive multiple calcinosis cutis in seronegative limited cutaneous scleroderma (CREST variant): A case report. World J Clin Cases 2026; 14(25): 123670
URL: https://www.wjgnet.com/2307-8960/full/v14/i25/123670.htm
DOI: https://dx.doi.org/10.12998/wjcc.123670

Lee HY, Lee SK, Kim H, Kang SW. Extensive multiple calcinosis cutis in seronegative limited cutaneous scleroderma (CREST variant): A case report. World J Clin Cases 2026; 14(25): 123670 [DOI: 10.12998/wjcc.123670]

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