Large cell neuroendocrine carcinoma of the distal common bile duct: A case report and literature review

doi:10.12998/wjcc.123303

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Cases. Aug 26, 2026; 14(24): 123303
Published online Aug 26, 2026. doi: 10.12998/wjcc.123303

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Figure 3 Clinical timeline. March 2025 [admission, multidisciplinary team (MDT)] → April 2, 2025 (percutaneous transhepatic cholangial drainage) → April 14, 2025 (laparoscopic pancreaticoduodenectomy) → postoperative pathology (large cell neuroendocrine carcinoma, proficient mismatch repair, R1) → MDT discussion [exclusion of immunotherapy, selection of etoposide plus (EP) regimen] → May–August 2025 (EP × 6 cycles) → September 2025 (negative computed tomography) → April 2026 (last follow-up, disease-free survival). MDT: Multidisciplinary team; PTCD: Percutaneous transhepatic cholangial drainage; LPD: Laparoscopic pancreaticoduodenectomy; EP: Etoposide plus cisplatin; LCNEC: Large cell neuroendocrine carcinoma.

Citation: Zheng BQ, Wang ZP, Feng RZ, Zheng ZC, Wang HJ, Wang H, Tuo HF. Large cell neuroendocrine carcinoma of the distal common bile duct: A case report and literature review. World J Clin Cases 2026; 14(24): 123303
URL: https://www.wjgnet.com/2307-8960/full/v14/i24/123303.htm
DOI: https://dx.doi.org/10.12998/wjcc.123303

Zheng BQ, Wang ZP, Feng RZ, Zheng ZC, Wang HJ, Wang H, Tuo HF. Large cell neuroendocrine carcinoma of the distal common bile duct: A case report and literature review. World J Clin Cases 2026; 14(24): 123303 [DOI: 10.12998/wjcc.123303]

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