Aprepitant as add-on to standard antiemetic regimen for concurrent chemoradiotherapy induced nausea vomiting in head and neck cancer

Table 1 Details of antiemetic regimens in the two study groups

Group A (aprepitant + ondansetron + dexamethasone)	Group B (ondansetron + dexamethasone)
On day 1 (half hour before CCRT)
Inj. ondansetron 8 mg IV	Inj. ondansetron 8 mg IV
Inj. dexamethasone 12 mg IV	Inj. dexamethasone 12 mg IV
Cap aprepitant 125 mg OD	Cap placebo OD
After CCRT
Tab. ondansetron 8 mg	Tab. ondansetron 8 mg
On day 2, 3, 4, and 5
Cap Aprepitant 80 mg OD on day 2, 3	Cap placebo OD on day 2, 3
Tab ondansetron 8 mg BD on days 2, 3, 4, and 5	Tab ondansetron 8 mg BD on days 2, 3, 4, and 5

CCRT: Concurrent chemo-radiotherapy; OD: Once daily; BD: Twice daily; IV: Intravenous.