From anticoagulation to intervention: The expanding role of percutaneous therapies in pulmonary embolism

doi:10.12998/wjcc.120219

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World Journal of Clinical Cases

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2307-8960

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World J Clin Cases. Jun 26, 2026; 14(18): 120219
Published online Jun 26, 2026. doi: 10.12998/wjcc.120219

Table 4 Emerging catheter technologies and investigational systems in pulmonary embolism intervention

Device/platform	Concep/device principle	Regulatory position (United States/European Union)	Trial/registry name	Identifier	Sample size (n)
AlphaVac F18 (AngioDynamics)	Mechanical thrombectomy based on aspiration (no extracorporeal circuit)	FDA cleared; CE marked	APEX-AV	NCT05318092	122
Helo PE (Endovascular Engineering)	Combined clot disruption + aspiration thrombectomy	Not approved (United States); not approved (European Union)	ENGULF	NCT05597891	25
WOLF (Boston Scientific)	Controlled thrombus extraction using finger-like retrieval elements	Approved for peripheral arteries; not approved specifically for PE (United States); not approved (European Union)	N/A	N/A	N/A
JET (Abbott)	High-pressure saline jet to fragment thrombus and facilitate aspiration	Approved for peripheral arteries; not approved for PE (United States); not approved (European Union)	N/A	N/A	N/A
Laguna (Innova Vascular)	Hybrid mechanical disruption plus aspiration	Approved for peripheral arteries; not approved for PE (United States); not approved (European Union)	TRUST	NCT06041594	107 (estimated)
Cleaner Pro (Argon Medical Devices)	Pharmacomechanical approach combining thrombectomy with local lytic infusion capability	Approved for peripheral arteries; not approved for PE ((United States); not approved (European Union)	CLEAN-PE	NCT06189313	125 (estimated)
Katana (Akura Medical)	Rheolytic-powered aspiration with directional control features	Not approved (United States); not approved (European Union)	QUADRA-PE	NCT06672510	118 (estimated)
Magneto eTrieve (Magneto Thrombectomy Solutions)	Large-bore aspiration combined with electromechanical clot extraction	Not approved (United States); not approved (European Union)	Safety and Performance of Magneto PE Kit	NCT04949048	10

FDA: Food and Drug Administration; CE: European conformity; PE: Pulmonary embolism; N/A: Not applicable.

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Citation: Latsios G, Ktenopoulos N, Koliastasis L, Apostolos A, Kachrimanidis I, Vlachakis PK, Tolis E, Mantziaris V, Stroumpouli E, Tsalamandris S, Drakopoulou M, Synetos A, Tsioufis K, Toutouzas K. From anticoagulation to intervention: The expanding role of percutaneous therapies in pulmonary embolism. World J Clin Cases 2026; 14(18): 120219
URL: https://www.wjgnet.com/2307-8960/full/v14/i18/120219.htm
DOI: https://dx.doi.org/10.12998/wjcc.120219

Latsios G, Ktenopoulos N, Koliastasis L, Apostolos A, Kachrimanidis I, Vlachakis PK, Tolis E, Mantziaris V, Stroumpouli E, Tsalamandris S, Drakopoulou M, Synetos A, Tsioufis K, Toutouzas K. From anticoagulation to intervention: The expanding role of percutaneous therapies in pulmonary embolism. World J Clin Cases 2026; 14(18): 120219 [DOI: 10.12998/wjcc.120219]

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