Direct oral anticoagulants vs low-molecular-weight heparins for cancer-associated thromboembolism

Table 2 Meta-regression table for outcomes

Variable	Estimate	P value	95% confidence interval	tau2	I2 (%)	R2 (%)
Meta-regression table for major bleeding
Age	-0.0001	0.9977	-0.082 to 0.0817	0.188	60.02	0.00
BMI	-0.0937	0.2118	-0.240 to 0.053	0.00	0.00	100
Creatinine	0.5628	0.1038	-0.115 to 1.240	0.044	17.42	57.23
Females	0.4637	0.2794	-0.376 to 1.303	0.191	65	9.93
Metastasis	1.906	0.008	0.497-3.315	0.094	48.59	58.38
Platelets	-0.218	0.38	-0.706 to 0.269	0.018	7.62	0.00
Meta-regression table for minor bleeding
Age	-0.046	0.338	-0.140 to 0.048	0.138	27.92	0.00
Females	3.13	0.036	0.204-6.055	0.00	0.00	100
Metastasis	1.324	0.436	-2.007 to 4.655	0.083	18.7	31.78
Meta-regression table for all-cause mortality
Age	-0.017	0.373	-0.057 to 0.021	0.05	71.01	0.48
BMI	-0.012	0.832	-0.122 to 0.098	0.044	39.07	0.00
Creatinine	0.341	0.066	-0.023 to 0.706	0.034	63.26	23.99
Females	1.396	0.116	-0.346 to 3.140	0.261	92.82	15.48
Metastasis	0.668	0.026	0.079-1.257	0.019	52.2	45.59
Thrombocytopenia	0.277	0.009	0.486-0.067	0.009	35.75	56.19
Meta-regression table for venous thromboembolism
Age	0.0016	0.95	-0.050 to 0.053	0.071	46.36	0.00
BMI	-0.05	0.48	-0.191 to 0.090	0.128	41.53	0.00
Creatinine	-0.206	0.447	-0.739 to 0.326	0.033	26.18	0.00
Females	-0.554	0.267	-1.536 to 0.426	0.341	88.24	4.64
Metastasis	0.053	0.922	-1.019 to 1.125	0.089	57.65	0.00
Platelets	0.100	0.576	-0.251 to 0.451	0.013	10.66	0.00

BMI: Body mass index.