Systematic review of multidisciplinary team strategies and novel research in rare and complex clinical cases

doi:10.12998/wjcc.v14.i16.119831

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Cases. Jun 6, 2026; 14(16): 119831
Published online Jun 6, 2026. doi: 10.12998/wjcc.v14.i16.119831

Table 4 Evidence synthesis of included studies[18-22,26,27,45-49]

Dimensions	Findings
Clinical domains	Oncology (dominant), cardiology, autoimmune disease
MDT composition	Oncologists, surgeons, radiologists, pathologists, geneticists, cardiologists, nurses, bioinformaticians
MDT format	In-person MDTs, molecular tumor boards, virtual/tele-MDTs
Innovation integrated	NGS, molecular profiling, AI/ML decision tools, liquid biopsy, precision therapeutics
Primary MDT function	Diagnostic clarification, treatment selection, escalation/de-escalation decisions
Outcomes reported	Diagnostic reclassification, altered management, feasibility of innovation integration
Survival/quality-of-life data	Limited direct reporting; mostly surrogate and process outcomes
Study design heterogeneity	Case reports → cohorts → qualitative and consensus studies
Geographic distribution	Europe, North America, Latin America

MDT: Multidisciplinary team; NGS: Next-generation sequencing; AI: Artificial intelligence; ML: Machine learning.

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Citation: Gavkare AM, Nanaware NL, Darade R, Dhotre SV, Mumbre SS, Nagoba BS. Systematic review of multidisciplinary team strategies and novel research in rare and complex clinical cases. World J Clin Cases 2026; 14(16): 119831
URL: https://www.wjgnet.com/2307-8960/full/v14/i16/119831.htm
DOI: https://dx.doi.org/10.12998/wjcc.v14.i16.119831

Gavkare AM, Nanaware NL, Darade R, Dhotre SV, Mumbre SS, Nagoba BS. Systematic review of multidisciplinary team strategies and novel research in rare and complex clinical cases. World J Clin Cases 2026; 14(16): 119831 [DOI: 10.12998/wjcc.v14.i16.119831]

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