Refractory rosuvastatin-associated necrotizing autoimmune myopathy: A case report and review of literature

Table 1 Laboratory and autoimmune testing results on admission and during hospital stay

Laboratory test	Result	Reference range
White blood cell count (cells/µL)	12.92 × 10³	4.8-10.8 × 10³
Hemoglobin (g/dL)	8.1	12-16
Hematocrit	25.8%	37%-47%
Mean corpuscular volume (fL)	105.7	80-100
Platelet count (cells/µL)	348 × 10³	130-400 × 10³
Sodium (mmol/L)	138	136-145
Potassium (mmol/L)	3.7	3.5-5.1
Chloride (mmol/L)	107	98-107
Bicarbonate (mEq/L)	15	22-29
Blood urea nitrogen (mg/dL)	56	8-22
Creatinine (mg/dL)	4.0	0.7-1.2
Glucose (mg/dL)	91	70-104
Calcium (mg/dL)	8.3	8.8-10.2
Total bilirubin (mg/dL)	0.24	0.20-1.0
Aspartate transaminase (U/L)	365	10-30
Alanine transaminase (U/L)	280	10-36
Alkaline phosphatase (U/L)	74	32-104
Creatine kinase (U/L)	9012	24-173
Erythrocyte sedimentation rate (mm/hour)	23	0-20
Urinalysis	Heme-positive urine with absent erythrocytes on microscopy; leukocytes present; 4+ bacteria
Jo-1 antibody (U)	Negative	< 1.0
SSA/Ro antibody (U)	Negative	< 1.0
SSB/La antibody (U)	Negative	< 1.0
Smith antibody (U)	Negative	< 1.0
RNP antibody (U)	Negative	< 1.0
Scl-70 antibody (U)	Negative	< 1.0
Antinuclear antibody (U)	Negative	≤ 1.0
Cyclic citrullinated peptide antibody (U)	Negative	< 20.0
HMG-CoA reductase antibody (CU)	Positive (348.8)	< 20.0

SSA: Sjögren syndrome-related antigen A; SSB: Sjögren syndrome–related antigen B; RNP: Ribonucleoprotein; Scl-70: Topoisomerase I; HMG-CoA: 3-hydroxy-3-methylglutaryl-coenzyme A.