Size-biology paradox in ampullary tumours - large-cell neuroendocrine carcinoma of the ampulla of Vater: A case report

doi:10.12998/wjcc.v14.i12.120145

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Case Report

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Cases. Apr 26, 2026; 14(12): 120145
Published online Apr 26, 2026. doi: 10.12998/wjcc.v14.i12.120145

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Figure 3 Histopathological findings of large-cell neuroendocrine carcinoma of the ampulla of Vater (× 200). A: Neoplastic cells with a high nuclear-to-cytoplasmic ratio arranged in solid sheets; B: Focal tubular formation within the tumour, indicating an adenocarcinoma component; C: Diffuse immunohistochemical positivity for chromogranin; D: High Ki-67 proliferation index consistent with a high-grade neuroendocrine carcinoma.

Citation: Florou E, Velayutham A, Zen Y, Waters J, Srinivasan P. Size-biology paradox in ampullary tumours - large-cell neuroendocrine carcinoma of the ampulla of Vater: A case report. World J Clin Cases 2026; 14(12): 120145
URL: https://www.wjgnet.com/2307-8960/full/v14/i12/120145.htm
DOI: https://dx.doi.org/10.12998/wjcc.v14.i12.120145

Florou E, Velayutham A, Zen Y, Waters J, Srinivasan P. Size-biology paradox in ampullary tumours - large-cell neuroendocrine carcinoma of the ampulla of Vater: A case report. World J Clin Cases 2026; 14(12): 120145 [DOI: 10.12998/wjcc.v14.i12.120145]

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