Comparing lebrikizumab with other systemic immunomodulators for moderate to severe atopic dermatitis: An updated systematic review

doi:10.12998/wjcc.v14.i12.119171

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Cases. Apr 26, 2026; 14(12): 119171
Published online Apr 26, 2026. doi: 10.12998/wjcc.v14.i12.119171

Table 1 Summary of risk of bias assessment for randomized controlled trials (n = 25)

Risk of bias rating	n (%)	Specific trials
Low risk across all domains	22 (88)	20 original trials + Warren et al[2], 2025 + Tanaka et al[3], 2024
Some concerns	3 (12)	1 small phase 2 trial (randomization), 1 trial (missing data), Guttman-Yassky et al[1], 2025 (open-label extension)
High risk	0 (0)	None

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Citation: Alphonse C, Irfan M, Céspedes SCT, Nwanejuafor C, Nayeem K, Hertan E, Mohan V, Gupta H, Fatima NUA, Mendoza LAG, Sardar A, Diaz AM, Jawed I. Comparing lebrikizumab with other systemic immunomodulators for moderate to severe atopic dermatitis: An updated systematic review. World J Clin Cases 2026; 14(12): 119171
URL: https://www.wjgnet.com/2307-8960/full/v14/i12/119171.htm
DOI: https://dx.doi.org/10.12998/wjcc.v14.i12.119171

Alphonse C, Irfan M, Céspedes SCT, Nwanejuafor C, Nayeem K, Hertan E, Mohan V, Gupta H, Fatima NUA, Mendoza LAG, Sardar A, Diaz AM, Jawed I. Comparing lebrikizumab with other systemic immunomodulators for moderate to severe atopic dermatitis: An updated systematic review. World J Clin Cases 2026; 14(12): 119171 [DOI: 10.12998/wjcc.v14.i12.119171]

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