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Case Report
©The Author(s) 2025.
World J Clin Cases. Nov 26, 2025; 13(33): 113312
Published online Nov 26, 2025. doi: 10.12998/wjcc.v13.i33.113312
Table 2 Clinical, endoscopic, and histopathological features and differential diagnoses of upper gastrointestinal involvement of Crohn’s disease
Category
Key features/findings
Clinical symptomsEpigastric discomfort, epigastric pain, vomiting, dysphagia, weight loss, anorexia
Endoscopic findingsAphthous ulcers, linear ulcers, cobblestone appearance of the mucosa, erosions, esophageal stricture, gastric outlet obstruction, duodenal stricture
Histopathological featuresNoncaseating granulomas, chronic active inflammation, lymphoid follicular hyperplasia
Differential diagnosesEsophagus-reflux esophagitis, eosinophilic esophagitis, viral esophagitis, tuberculous esophagitis, Stomach-Helicobacter pylori gastritis, NSAID-induced gastritis, tuberculous gastritis, Ménétrier’s disease, gastric lymphoma, Duodenum-peptic ulcer disease, celiac disease, tuberculous duodenitis, Brunner’s gland hyperplasia, duodenal lymphoma


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