Impact of type 2 diabetes mellitus on interstitial lung disease risk in rheumatoid arthritis

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Clin Cases. Nov 26, 2025; 13(33): 110641
Published online Nov 26, 2025. doi: 10.12998/wjcc.v13.i33.110641

Table 1 Baseline characteristics before matching, n (%)/mean ± SD

Baseline characteristics	RA+DM (n = 60523)	RA-DM (n = 138848)	P value
Age	69.06 (11.56)	68.25 (14.41)	< 0.001
Gender
Female	42031 (69.45)	102277 (73.66)	< 0.001
Race
White	40840 (67.48)	108904 (78.43)	< 0.001
Black	10059 (16.62)	14765 (10.63)	< 0.001
Hispanic	6368 (10.52)	9481 (6.83)	< 0.001
Asian	1375 (2.27)	2718 (1.96)	< 0.001
Native	1196 (1.98)	1999 (1.44)	< 0.001
Other	685 (1.13)	990 (0.71)	< 0.001
Comorbidities
Gastro-esophageal reflux disease	21363 (35.3)	46663 (33.61)	< 0.001
Chronic obstructive pulmonary disease	7849 (12.97)	16699 (12.03)	< 0.001
Asthma	6271 (10.36)	12672 (9.13)	< 0.001
Smoking	5780 (9.55)	15831 (11.4)	< 0.001
Heart failure	29061 (48.02)	38053 (27.4)	< 0.001
Chronic kidney disease	20373 (33.66)	23650 (17.03)	< 0.001
Atrial fibrillation	9868 (16.3)	19183 (13.81)	< 0.001
Ventricular tachycardia	1065 (1.76)	1996 (1.44)	< 0.001
Hypertension	53568 (88.51)	99210 (71.45)	< 0.001
Obesity	19604 (32.39)	25059 (18.05)	< 0.001
Alcohol use	1132 (1.87)	4936 (3.55)	< 0.001
Steroids use	5767 (9.53)	15274 (11.0)	< 0.001
Coronary artery disease	21901 (36.19)	31360 (22.58)	< 0.001

RA: Rheumatoid arthritis; DM: Diabetes mellitus.

Citation: Sutton J, Khattar G, Saliba F, Mourad O, Aoun L, Jdaidani J, Qandil H, Kaspar C, Abu-Baker S, Almardini S, Haddadin F, Bou Sanayeh E, Slobodnick A. Impact of type 2 diabetes mellitus on interstitial lung disease risk in rheumatoid arthritis. World J Clin Cases 2025; 13(33): 110641
URL: https://www.wjgnet.com/2307-8960/full/v13/i33/110641.htm
DOI: https://dx.doi.org/10.12998/wjcc.v13.i33.110641

Sutton J, Khattar G, Saliba F, Mourad O, Aoun L, Jdaidani J, Qandil H, Kaspar C, Abu-Baker S, Almardini S, Haddadin F, Bou Sanayeh E, Slobodnick A. Impact of type 2 diabetes mellitus on interstitial lung disease risk in rheumatoid arthritis. World J Clin Cases 2025; 13(33): 110641 [PMID: 41356090 DOI: 10.12998/wjcc.v13.i33.110641]

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