Beyond the optic disc: Investigating gender-based differences in optic neuritis

Table 1 Ratio female:male in different pathologies

Condition	Female:male ratio	Ref.
Typical MS-related ON	2-3:1	Malik et al[5] and Arnett et al[4]
Multiple sclerosis (overall)	2.73:1 (95 %CI: 2.37-3.09)	Arnett et al[4]
AQP4-NMOSD (overall)	8.89:1	Arnett et al[4]
HIV-positive NMOSD	9-10:1	Borisow et al[6]
HIV-negative NMOSD	≈ 2:1	Borisow et al[6]
MOGAD	≈ 1:1 (some series female > male)	Jurynczyk et al[10] and de Mol et al[14]

MS: Multiple sclerosis; ON: Optic neuritis; AQP4-NMOSD: Aquaporin 4 IgG positive neuromyelitis optica spectrum disorder; NMOSD: Neuromyelitis optica spectrum disorder; MOGAD: Myelin oligodendrocyte glycoprotein antibody disease; HIV: Human immunodeficiency virus.