Acute cholangitis due to common bile duct stones: Clinical outcomes in patients with and without concurrent acute pancreatitis

Table 5 Univariate and multivariate analyses of factors associated with intensive care unit admission, n (%)

Factor		Univariate analysis		Multivariate analysis
		OR (95%CI)	P value	OR (95%CI)	P value
Age	Every 1-year increase	1.103 (1.050-1.159)	< 0.001	1.179 (1.012-1.373)	0.035
Sex	Male	2.218 (0.839-5.862)	0.108
WBC count		1.148 (0.555-1.230)	< 0.001	1.014 (0.875-1.174)	0.857
Acute pancreatitis	Yes	1.524 (0.670-4.186)	0.414
Severe plus moderate acute pancreatitis	Yes	5.462 (0.992-30.077)	0.051
Time to ERCP within 12 hours	Yes	6.880 (2.211-21.414)	< 0.001	11.984 (0.346-415.629)	0.170
Any ERCP-related AE	Yes	6.133 (1.800-20.897)	0.004	3.123 (0.125-77.908)	0.488
Cardiovascular dysfunction1	Yes	292.067 (62.939-1355.333)	< 0.001	1201.997 (28.078-51457.080)	< 0.001
Neurological dysfunction (conscious disturbance)	Yes	29.909 (9.935-90.038)	< 0.001	28.347 (1.829-439.339)	28.347
Respiratory dysfunction (PaO2/FiO2 ratio < 300)	Yes	Infinite	0.998
Renal dysfunction (Cr > 2.0 mg/dL)	Yes	2.229 (0.608-8.165)	0.226
Hepatic dysfunction (PT-INR > 1.5)	Yes	15.375 (3.135-75.408)	< 0.001	2.443 (0.077-77.235)	0.612
Hematological dysfunction (PLT < 100 × 103/µL)	Yes	3.010 (0.807-11.220)	0.101

¹Cardiovascular dysfunction: Hypotension requiring treatment with dopamine 5 µg/kg per minute, or any dose of norepinephrine.

AE: Adverse event; CI: Confidence interval; Cr: Creatine; ERCP: Endoscopic retrograde cholangiopancreatography; FiO₂: Fraction of inspired oxygen; OR: Odds ratio; PaO₂: Partial pressure of oxygen; PLT: Platelet; PT-INR: Prothrombin time-international normalized ratio.