Acute cholangitis due to common bile duct stones: Clinical outcomes in patients with and without concurrent acute pancreatitis

Table 1 Demographic, laboratory, and clinical characteristics, n (%)

Variables	AC with ABP, n = 90	AC without ABP, n = 268	P value
Age in years	73 (64-82)	63 (52-75)	0.305
Male sex	52 (57.8)	154 (57.5)	0.958
Body temperature in °C	37.4 (36.9-38.0)	37.5 (36.9-38.4)	0.797
WBC count as × 103/µL	13.1 (9.2-17.3)	10.4 (8.5-15.3)	0.007
Abnormal WBC count	55 (61.1)	124 (42.3)	0.015
AST in U/L	178.5 (83-261)	193 (111-468)	0.722
ALT in U/L	175 (89.5-290.5)	222 (136-447)	0.790
ALK-P in U/L	215 (135.5-300.5)	181 (123-267)	0.316
Total bilirubin in mg/dL	3.5 (2.1-5.3)	3.6 (2.5-6.2)	0.795
Creatinine in mg/dL	1.08 (0.90-1.27)	0.88 (0.73-1.15)	0.201
Amylase	1165 (611-2368)	47.6 (40.0-69.4)	< 0.01
Lipase	2054 (1128-4289)	28 (24-40)	< 0.01
Blood culture performed, n = 293	73 (81.1)	220 (82.1)	0.835
Positive blood culture	14/73 (19.2)	57/220 (25.9)	0.245
Gallbladder status
In situ with stone	55 (61.1)	156 (58.2)	0.069
In situ without stone	28 (31.1)	63 (23.5)	0.152
Post cholecystectomy	7 (7.8)	49 (18.3)	0.018
CBDS on images before ERCP	61 (67.8)	171 (63.8)	0.495
Abdominal ultrasound, n = 89	1/19 (5.3)	9/70 (12.9)	0.353
CT scan, n = 356	58/90 (64.4)	154/266 (57.9)	0.274
MRCP, n = 19	3/4 (75)	15/15 (100)	0.047
Median CBDS diameter in mm	5.6 (4.0-8.7)	6.8 (4.7-10.0)	0.775
Severity of AC
Mild	39 (43.3)	141 (52.6)	0.088
Moderate	28 (31.1)	71 (26.5)	0.397
Severe	23 (25.6)	56 (20.9)	0.356
Organ dysfunction
Cardiovascular	4 (4.4)	12 (4.5)	0.989
Neurological	6 (6.7)	14 (5.2)	0.606
Respiratory	6 (6.7)	7 (2.6)	0.075
Renal	11 (12.2)	20 (7.5)	0.165
Hepatic	4 (4.4)	3 (1.1)	0.044
Hematological	8 (8.9)	16 (6.0)	0.352

Data are presented as n (%) or median (interquartile range) unless otherwise defined. ABP: Acute biliary pancreatitis; AC: Acute cholangitis; ALK-P: Alkaline phosphatase; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; CBDS: Common bile duct stone; ERCP: Endoscopic retrograde cholangiopancreatography; MRCP: Magnetic resonance cholangiopancreatography.