Diagnostic accuracy of circulating miR-146, miR-221 and miR-222 in papillary thyroid cancer: A systematic review and meta-analysis

Table 2 Papillary thyroid cancer characteristics among the included studies

Ref.	Lymph node metastasis (n)	Distant metastasis (n)	Extrathyroid extension (n)	Multifocality (n)	PTC recurrence (n)	Tumor size
Lee et al[26]	45	0	40	NG	NG	Benign: 29.48 ± 11.25 mm. PTC (node negative): 10.50 ± 7.67 mm. PTC (node negative): 13.71 ± 8.29 mm
Zhang et al[24]	59	29	17	20	12	PTC (newly diagnosed)-64 were ≤ 2 cm and 21 were > 2 cm
Zhang et al[27]	61	40	18	34	NG	NG
Rosignolo et al[23]	32	3	24	12	NG	Screening cohort median size and range in mm: 11 (5-33). Validation cohort median and range in mm: 10 (1-60)
Yu et al[22]	60	20	NG	36	NG	PTC: 67 were ≤ 2 cm and 39 were > 2 cm
Jiang et al[25]	49	8	NG	20	3	PTC without LNM (mm): 10.6 ± 4.2 of which 2 were > 20 mm and 13 were ≤ 20 mm. PTC with LNM (mm): 13.5 ± 5.5 of which 8 were > 20 mm and 41 were ≤ 20 mm

PTC: Papillary thyroid cancer; LNM: Lymph node metastasis; NG: Not given.