Diagnostic accuracy of circulating miR-146, miR-221 and miR-222 in papillary thyroid cancer: A systematic review and meta-analysis

Table 1 Basic characteristics of the included studies

Ref.	Year	Country	Total PTC/BN/HC cases (n)	Male/females (n)	Age	miRNA tested
Lee et al[26]	2014	Korea	70/19/0	15/74	BN: 49.79 ± 12.49, PTC (no nodal involvement) 51.4 ± 12.66, PTC (with nodal involvement) 51.51 ± 15.34	miR-146b, miR-221, miR-222, miR-155
Zhang et al[24]	2017	China	85/35/40	50/110	PTC-49 were < 45 years, 36 were ≥ 45 years. BN: 21 were < 45 years and 19 were ≥ 45 years	miR-146b, miR-221, miR-222, miR-16
Zhang et al[27]	2018	China	58/35/40	NG	PTMC: 26 were < 45 years, 32 were ≥ 45 years. PTC: 31 were < 45 years, 16 were ≥ 45 years	miR-146b, miR-221, miR-222, miR-16, miR-21
Rosignolo et al[23]	2017	Italy	44/19/20	NG	NG	mi-146a-5p, miR-221-3p, miR-222-3p, miR-146b-5p, miR-191-5p, miR-103a-3p, miR-28-3p
Jiang et al[25]	2020	China	64/0/0	14/50	PTC without LNM: 42.2 ± 13. PTC with LNM: 41.0 ± 12.7	miR-21-52, miR-146b-5p, miR-204-5p, miR-221-3p, miR-222-3p, miR-451a, miR-7-5p, miR-30a-3p, miR-138-5p, miR-199a-3p
Yu et al[22]	2012	China/Canada	106/95/44	61/184	PTC: 65 were < 45 years and 41 were ≥ 41 years. BN: 60 were < 45 years and 35 were ≥ 45 years	let-7e, miR-181b, miR-1975, miR-144, miR-100, miR-151-5p, miR-222, miR-543, miR-127-3p, miR-16

PTC: Papillary thyroid cancer; BN: Benign nodule; HC: Healthy controls; PTMC: Thyroid papillary microcarcinoma; LNM: Lymph node metastasis; NG: Not given.