Hepatitis B virus and hepatitis D virus co-infection complicated by autoimmune hepatitis: Two case reports

Figure 1 Liver biopsy pathological results for case 1. A: A total of eleven small and medium-sized confluent areas were seen in the perforated liver tissue, with disorganized lobular architecture (hematoxylin and eosin); B: The main lesions were enlargement of most of the confluent areas, moderate inflammatory cell infiltration, predominantly single nucleated cells, and plasma cells were seen, often forming foci of lymphocyte aggregation, and mild-moderate interfacial inflammation (hematoxylin and eosin); C: The small bile ducts were discernible, and the biliary epithelium was irregularly arranged, and a mild-moderate fine biliary reaction was seen in the periphery of the confluent areas; fibroblastic tissue hyperplasia was seen in the confluent area, and the fibrous intervals of the bridge were formed, which destroyed the hepatic lobules by separating the hepatic parenchyma. Hepatocellular lipoatrophy and ballooning were seen in the lobules (hematoxylin and eosin); D: With focally necrotic and apoptotic vesicles, and mild inflammatory cell infiltration in the sinusoids, with some hepatocytes with ground-glass lesions (hematoxylin and eosin).