Role of nitric oxide, prostaglandins, thromboxanes and endothelins in lung cancer: An overview

doi:10.12998/wjcc.v13.i25.107907

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Sep 6, 2025 (publication date) through Jul 12, 2025

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World Journal of Clinical Cases

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World J Clin Cases. Sep 6, 2025; 13(25): 107907
Published online Sep 6, 2025. doi: 10.12998/wjcc.v13.i25.107907

Table 3 Effects of prostaglandins on lung cancer models

Factor	Models	Effects	Ref.
Prostaglandin D₂	A549 cell line	Apoptosis	[65]
Prostaglandin I₂	A549 cell line	Anti-growth	[66]
	LLC	Anti-metastatic	[67]
	LLC	Anti-metastatic	[68]
	Transgenic mice	Chemopreventive	[69]
Prostaglandin E₂	NSCLC	Growth	[70]
	A549 and PC-9 cell lines	Pro-tumorigenic	[71]
	A549 and GLC82 cell lines	Proliferative	[72]
	NSCLC cell line	Apoptosis resistance	[73]
	A549 cell line	Anti-apoptotic	[74]
	A549 cell line and lung cancer mice	Multidrug resistance	[75]
	Lung cancer patients	Tumorigenic	[76]
	A549 cell line	Migratory	[77]
	NSCLC cell line	Invasive	[78]
	A549 cell line	Tumorigenic	[79]
	NSCLC cell line	Proliferative	[80]
	NSCLC cells	Metastatic	[81]
	NCI-H157 cell line	Angiogenic	[82]
	NSCLC patients	Immunosuppressive	[83]
	A549 cell line	Migratory	[84]

NSCLC: Non-small cell lung cancer; LLC-1: Lewis lung carcinoma.

Citation: Demirel S, Sinag IN. Role of nitric oxide, prostaglandins, thromboxanes and endothelins in lung cancer: An overview. World J Clin Cases 2025; 13(25): 107907
URL: https://www.wjgnet.com/2307-8960/full/v13/i25/107907.htm
DOI: https://dx.doi.org/10.12998/wjcc.v13.i25.107907