Off-label use of treprostinil in adult patients in clinical cases

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Cases. Aug 16, 2025; 13(23): 107279
Published online Aug 16, 2025. doi: 10.12998/wjcc.v13.i23.107279

Table 1 Treprostinil mechanisms of action

Number	Effect
1	Vasodilation
2	Inhibition of platelets aggregation
3	Inhibition of platelets adherence
4	Reversion of pulmonary remodelling
5	Decrease of muscle cell proliferation rate
6	Regulation of vascular homeostasis
7	Attenuation of inflammatory response
8	Upregulation of apoptosis rate
9	Elevation of ATP production
10	Preservation of mitochondrial biogenesis

Citation: Mouratidou C, Pavlidis ET, Katsanos G, Kotoulas SC, Tsoulfas G, Mouloudi E, Taitzoglou IA, Galanis IN, Pavlidis TE. Off-label use of treprostinil in adult patients in clinical cases. World J Clin Cases 2025; 13(23): 107279
URL: https://www.wjgnet.com/2307-8960/full/v13/i23/107279.htm
DOI: https://dx.doi.org/10.12998/wjcc.v13.i23.107279

Mouratidou C, Pavlidis ET, Katsanos G, Kotoulas SC, Tsoulfas G, Mouloudi E, Taitzoglou IA, Galanis IN, Pavlidis TE. Off-label use of treprostinil in adult patients in clinical cases. World J Clin Cases 2025; 13(23): 107279 [PMID: 40821411 DOI: 10.12998/wjcc.v13.i23.107279]

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