Role of immature granulocyte and blood biomarkers in predicting perforated acute appendicitis using machine learning model

Table 1 Comparison of different groups stratified by acute appendicitis status, using pairwise

Variables (median)	Control (n = 41)	AAp (n = 99)	P value	Control (n = 41)	Uncomplicated AAp (n = 65)	P value	Control (n = 41)	Complicated (n = 34)	P value	Uncomplicated AAp (n = 65)	Complicated AAp (n = 34)	P value
Age (year)	43 (37-54)	33 (32-39)	0.003	43 (37-54)	33 (31-40)	0.001	43 (37-54)	36 (32-47)	0.131	33 (31-40)	36 (32-47)	0.091
Platelet	258 (243-291)	248 (237-263)	0.349	258 (243-291)	247 (236-264)	0.381	258 (243-291)	253 (230-276)	0.459	247 (236-264)	253 (230-276)	0.985
Total bilirubin	0.61 (0.49-0.73)	0.73 (0.63-0.87)	0.254	0.61 (0.49-0.73)	0.67 (0.62-0.82)	0.337	0.61 (0.49-0.73)	0.93 (0.61-1.13)	0.187	0.67 (0.62-0.82)	0.93 (0.61-1.13)	0.329
WBC	6.8 (6.5-7.6)	14.5 (13.5-15.3)	< 0.001	6.8 (6.5-7.6)	13.6 (12.9-14.7)	< 0.001	6.8 (6.5-7.6)	15.8 (14.6-16.8)	< 0.001	13.6 (12.9-14.7)	15.8 (14.6-16.8)	0.009
Neutrophil	3.98 (3.70-4.45)	11.5 (10.5-12)	< 0.001	3.98 (3.70-4.45)	10.7 (9.9-12.6)	< 0.001	3.98 (3.70-4.45)	12.2 (11.5-13.8)	< 0.001	10.7 (9.9-12.6)	12.2 (11.5-13.8)	0.047
Lymphocyte	2.5 (2.2-2.6)	2.1 (1.8-2.5)	0.088	2.5 (2.2-2.6)	2 (1.7-2.5)	0.057	2.5 (2.2-2.6)	2.2 (1.8-2.8)	0.400	2 (1.7-2.5)	2.2 (1.8-2.8)	0.401
Monocyte	0.42 (0.39-0.47)	0.69 (0.62-0.73)	< 0.001	0.42 (0.39-0.47)	0.6 (0.6-0.7)	< 0.001	0.42 (0.39-0.47)	0.81 (0.73-0.95)	< 0.001	0.6 (0.6-0.7)	0.81 (0.73-0.95)	0.001
NLR	1.7 (1.6-2.0)	5.81 (5-6.68)	< 0.001	1.7 (1.6-2.0)	6 (4.46-7)	< 0.001	1.7 (1.6-2.0)	5.7 (5.1-7.3)	< 0.001	6 (4.46-7)	5.7 (5.1-7.3)	0.491
LMR	5.97 (5.45-6.64)	2.81 (2.56-3.14)	< 0.001	5.97 (5.45-6.64)	2.9 (2.6-3.5)	< 0.001	5.97 (5.45-6.64)	2.53 (2.16-3.14)	< 0.001	2.9 (2.6-3.5)	2.53 (2.16-3.14)	0.038
MPV	9.6 (9.1-10)	10.3 (10.1-10.6)	0.003	9.60 (9.10-10.2)	10.3 (9.9-10.6)	0.009	9.60 (9.10-10.2)	10.2 (9.8-10.8)	0.009	10.3 (9.9-10.6)	10.2 (9.8-10.8)	0.693
IG (× 103/μL)	0.01 (0.01-0.01)	0.02 (0.02-0.03)	< 0.001	0.01 (0.01-0.01)	0.02 (0.02-0.03)	< 0.001	0.01 (0.01-0.01)	0.03 (0.03-0.06)	< 0.001	0.02 (0.02-0.03)	0.03 (0.03-0.06)	0.001
IG (%)	0.10 (0.10-0.20)	0.1 (0.1-0.2)	< 0.001	0.10 (0.10-0.20)	0.11 (0.10-0.20)	< 0.001	0.10 (0.10-0.20)	0.20 (0.20-0.40)	< 0.001	0.11 (0.10-0.20)	0.20 (0.20-0.40)	0.018
Neutrophil to IG ratio	330 (15-387)	495 (440-570)	< 0.001	330 (15-387)	513 (453-593)	< 0.001	330 (15-387)	442 (383-553)	0.001	513 (453-593)	442 (383-553)	0.182
Ferritin	34 (26-65)	71.3 (35.5-117)	0.070	34 (26-65)	84 (41-124)	0.044	34 (26-65)	30 (25-163)	0.440	84 (41-124)	30 (25-163)	0.490

AAp: Acute appendicitis; IG: Immature granulocytes; MPV: Mean platelet volume; NLR: Neutrophil-to-lymphocyte ratio; LMR: Lymphocyte-to-monocyte ratio; WBC: White blood cell.