Total adenosine deaminase cases as an inflammatory biomarker of pleural effusion syndrome

Table 4 Measures of diagnostic parameters of adenosine deaminase following selection of the best cutoff point for pleural inflammatory diseases according to the Youden index in the receiver operating characteristic curve

Diagnostic parameter	Result (%)2	95%CI
Best cutoff (U/L)	≥ 9.00	-
Sensitivity	77.69	69.22-84.75
Specificity	68.75	49.99-83.88
Positive predictive value or precision	90.38	83.03-95.29
Negative predictive value	44.90	30.67-59.77
Positive likelihood ratio1	2.48	2.21-11.2
Negative likelihood ratio1	0.32	0.27-0.51
Diagnostic odds radio	7.65	0.78-18.34
Diagnostic or predictive accuracy1	75.82	68.24-82.37
Disease prevalence1	50.48	44.78-56.17

¹These values are dependent on disease prevalence.

²χ² = 29.5138 (2-Sided P-value= 0.00001). Statnote: The Youden index at the receiver operating characteristic curve is the optimal cutoff value that provides the best tradeoff between sensitivity and specificity.