Correlations of vancomycin trough concentration and its efficacy and toxicity in patients in the intensive care unit

Table 4 Univariate logistic analyses between pharmacokinetics and clinical characteristics and nephrotoxicity, n (%)

Variable	Non-nephrotoxic (n = 76)	Nephrotoxic (n = 27)	OR	95%CI	P value
Sex			1.0960	0.430-2.977	0.8509
Female	24 (31.6)	8 (29.6)	-	-	-
Male	52 (68.4)	19 (70.4)	-	-	-
Age (years)			1.2620	0.522-3.068	0.6046
≤ 65	41 (53.9)	13 (46.4)	-	-	-
> 65	35 (46.1)	14 (53.6)	-	-	-
Weight (kg)			1.1770	0.486-2.927	0.7193
≤ 60	34 (44.7)	11 (40.7)	-	-	-
> 60	42 (55.3)	16 (59.3)	-	-	-
Main etiologies of ICU cases			1.0710	0.347-2.994	0.8987
Postoperative infection	60 (78.9)	21 (77.8)	-	-	-
Other	16 (21.1)	6 (22.2)	-	-	-
Comorbidities			1.0750	0.292-5.141	0.9190
No	9 (11.8)	3 (11.1)	-	-	-
Yes	67 (88.2)	24 (88.9)	-	-	-
Infectious site			0.7187	0.432-1.147	0.1808
Abdominal cavity	18 (23.7)	4 (14.8)	-	-	-
Lung	23 (30.2)	12 (44.4)	-	-	-
Blood	27 (35.5)	9 (33.3)	-	-	-
Chest cavity	7 (9.2)	3 (11.1)	-	-	-
Daily dose (g)			1.4650	0.582-3.947	0.4289
≤ 1.65	29 (38.2)	8 (29.6)	-	-	-
> 1.65	47 (61.8)	19 (70.4)	-	-	-
APACHE II score			0.5580	0.220-1.356	0.2047
≤ 35	37 (48.7)	17 (63.0)	-	-	-
> 35	39 (51.3)	10 (37.0)	-	-	-
Mechanical ventilation			0.4510	0.177-1.160	0.0945
No	18 (23.7)	11 (40.7)	-	-	-
Yes	58 (76.3)	16 (38.2)	-	-	-
Cmin (μg/mL)			1.8940	0.771-4.663	0.1612
≤ 14.0	51 (67.1)	14 (51.9)	-	-	-
> 14.0	25 (32.9)	13 (48.1)	-	-	-
AUC0-24			1.9170	0.792-4.731	0.1508
≤ 500.5	46 (60.5)	12 (44.4)	-	-	-
> 500.5	30 (39.5)	15 (55.5)	-	-	-
AUC0-24/MIC			1.3760	0.565-3.485	0.4880
≤ 522.1	34 (44.7)	10 (37.0)	-	-	-
> 522.1	42 (55.3)	17 (63.0)	-	-	-

Data are presented as n (%). APACHE: Acute physiological chronic health evaluation; AUC: Area under the curve; CI: Confidence interval; C_min: Trough concentration; ICU: Intensive care unit; MIC: Minimum inhibitory concentration; OR: Odds ratio.