Value of glucose transport protein 1 expression in detecting lymph node metastasis in patients with colorectal cancer

Table 5 The correlation between hypoxia-induced factor-1 expression and clinicopathologic parameters

	HIF-1 (center)		P value	HIF-1 (periphery)		P value
	(-) (n = 94)	(+) (n = 72)		(-) (n = 89)	(+) (n = 75)
Age (yr), mean ± SD	64.0 ± 12.4	65.1 ± 11.5	0.576	63.5 ± 12.6	65.6 ± 11.3	0.246
Sex
Male	59	45	0.972	58	45	0.495
Female	35	27		31	30
Tumor size (mean ± SD)	4.7 ± 1.7	5.5 ± 2.2	0.014	4.8 ± 1.7	5.3 ± 2.2	0.082
T stage
T1, 2	17	6	0.071	16	7	0.112
T3, 4	77	66		73	68
N stage
N0	59	38	0.196	57	40	0.164
N1-2	35	34		32	35
AJCC stage
I, II	57	38	0.310	55	40	0.274
III, IV	37	34		34	35
Lymphatic invasion
Negative	80	60	0.755	76	62	0.634
Positive	14	12		13	13
Perineural invasion
Negative	77	59	0.996	73	61	0.909
Positive	17	13		16	14
Blood glucose level (mean ± SD)	109.91 ± 30.8	112.29 ± 32.6	0.632	108.97 ± 32.2	113.69 ± 31.1	0.342
SUVmax of primary tumor (mean ± SD)	14.0 ± 7.1	14.0 ± 7.6	0.979	14.2 ± 7.0	13.8 ± 7.9	0.754
SUVmax of lymph node (mean ± SD)	1.4 ± 2.9	2.0 ± 2.9	0.229	1.6 ± 2.9	1.8 ± 2.9	0.713

HIF-1: Hypoxia-inducible factor-1; SD: Standard deviation; AJCC: American Joint Committee on Cancer; SUV: Standardized uptake value.