Inverse relationship between platelet Akt activity and hippocampal atrophy: A pilot case-control study in patients with diabetes mellitus

doi:10.12998/wjcc.v12.i2.302

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Cases. Jan 16, 2024; 12(2): 302-313
Published online Jan 16, 2024. doi: 10.12998/wjcc.v12.i2.302

Table 1 Characteristics of the study subjects

Parameters	DM group	Control group
Total number (F/M)	40 (20/20)	15 (8/7)
Age (years)	75.0 ± 7.6	73.4 ± 7.0
DM duration (years)	13.6 ± 11.3	None
Height (cm)	156.7 ± 8.8	158.5 ± 8.3
Weight (kg)	57.0 ± 10.5	57.8 ± 7.1
BMI	23.2 ± 3.8	23.0 ± 2.6
sBP (mmHg)	124.5 ± 19.3	130.0 ± 15.7
dBP (mmHg)	67.8 ± 13.6	74.4 ± 11.6
HbA1c (%)	8.1 ± 1.4^d	5.9 ± 0.2
Glu (mg/dL)	175.0 ± 54.2^d	99.3 ± 13.3
TC (mg/dL)	185.1 ± 33.3	201.6 ± 29.4
TG (mg/dL)	119.1 ± 53.7	110.7 ± 57.0
HDL (mg/dL)	53.6 ± 14.4	61.9 ± 13.7
Plt (× 10⁴/μL)	21.4 ± 5.9	23.8 ± 3.7
VSRAD Z-score	0.841 ± 0.462	0.900 ± 0.489

^dP < 0.01, compared to the control group.

F: Female; M: Male; DM: Diabetes mellitus; BMI: Body mass index; sBP: Systolic blood pressure; dBP: Diastolic blood pressure; HbA1c: Hemoglobin A1c; Glu: Plasma glucose; TC: Total cholesterol; TG: Triglyceride; HDL: High-density lipoprotein; Plt: Platelet counts; VSRAD: Voxel-based specific regional analysis for Alzheimer’s Disease. The data are presented as the mean ± SD.

Citation: Tokuda H, Hori T, Mizutani D, Hioki T, Kojima K, Onuma T, Enomoto Y, Doi T, Matsushima-Nishiwaki R, Ogura S, Iida H, Iwama T, Sakurai T, Kozawa O. Inverse relationship between platelet Akt activity and hippocampal atrophy: A pilot case-control study in patients with diabetes mellitus. World J Clin Cases 2024; 12(2): 302-313
URL: https://www.wjgnet.com/2307-8960/full/v12/i2/302.htm
DOI: https://dx.doi.org/10.12998/wjcc.v12.i2.302