Different effects of 24 dietary intakes on gastroesophageal reflux disease: A mendelian randomization

Table 2 Heterogeneity and pleiotropy evaluations for genetically causal associations of 24 dietary intake with gastroesophageal reflux disease risk

Dietary intake	No. SNPs	Heterogeneity				Pleiotropy
		Q-MR Egger	Q-IVW	P-MR Egger	P-IVW	Intercept	SE	P value	MRPRESSO global test P
Pork intake	9	10.80	14.92	0.148	0.061	-0.028	0.018	0.146	0.091
Bacon intake	0	NA	NA	NA	NA	NA	NA	NA	NA
Processed meat intake	12	22.74	25.39	0.012	0.008	0.023	0.022	0.306	0.01
Cooked vegetable intake	9	9.61	9.86	0.212	0.275	0.036	0.032	0.242	0.314
Salad / raw vegetable intake	10	7.800	9.26	0.453	0.414	-0.011	0.009	0.262	0.39
Fresh fruit intake	37	119.23	124.00	4.05E-11	1.35E-11	-0.007	0.006	0.245	< 0.001
Dried fruit intake	26	66.08	69.47	8.43E-06	4.61E-06	0.012	0.011	0.278	< 0.001
Salted nuts intake	1	NA	NA	NA	NA	NA	NA	NA	NA
Unsalted nuts intake	0	NA	NA	NA	NA	NA	NA	NA	NA
Salted peanuts intake	0	NA	NA	NA	NA	NA	NA	NA	NA
Unsalted peanuts intake	1	NA	NA	NA	NA	NA	NA	NA	NA
Average weekly red wine intake	12	24.28	24.28	0.007	0.012	-0.001	0.016	0.974	0.043
Average weekly beer plus cider intake	11	12.74	13.36	0.175	0.204	-0.008	0.012	0.525	0.32
Coffee intake	26	43.08	45.59	0.010	0.007	-0.003	0.003	0.249	0.008
Tea intake	28	52.56	55.47	0.002	0.001	-0.004	0.003	0.241	0.002
Milk intake	2	NA	NA	NA	NA	NA	NA	NA	NA
Yogurt intake	1	NA	NA	NA	NA	NA	NA	NA	NA
Cheese intake	38	80.85	84.39	2.70E-05	1.45E-05	-0.009	0.007	0.217	< 0.001
Cereal intake	27	60.22	60.77	9.74E-05	1.32E-04	-0.004	0.007	0.638	0.003
Non-oily fish intake	5	4.17	4.86	0.244	0.302	-0.018	0.026	0.531	0.376
Oily fish intake	37	56.19	57.51	0.013	0.013	0.004	0.005	0.369	0.015
Lamb intake	0	NA	NA	NA	NA	NA	NA	NA	NA
Beef intake	19	4.43	11.58	0.619	0.115	0.031	0.012	0.037	0.138
Bread intake	7	42.02	42.04	0.001	0.001	0.001	0.007	0.928	0.002

SNPs: Single nucleotide polymorphisms; IVW: Inverse variance weighted; SE: Standard error.