Diabetic foot ulcer: A comprehensive review of pathophysiology and management modalities

Table 3 Overview of diabetic foot management strategies

Treatment modality	Level of evidence	Strength of recommendation
Non-invasive modalities
Wound dressing	High	Strong recommendation
Antibiotics	Low to moderate	Strong recommendation
Total-contact casting and pressure offloading techniques	High	Strong recommendation
Maggot therapy	Low	Weak recommendation
Hyperbaric oxygen	Low	Weak recommendation
Topical growth factors	Moderate	Could be beneficial
Cell therapy	Low (more studies required)	Weak recommendation
Invasive modalities
Debridement	Moderate to high	Strong recommendation
Skin grafting	Moderate	Could be beneficial
Revascularization	Moderate	Strong recommendation