Hyperthyroidism and severe bradycardia: Report of three cases and review of the literature

Table 3 Treatment and outcome of 34 cases of hyperthyroidism and severe bradycardia

Number	Hyperthyroidism treatment	Bradycardia drug treatment	Temporary pacemaker	ECG changes after treatment1	Bradycardia recovery time in d	Permanent pacemaker
1	Propylthiouracil	Isoproterenol, atropine, prednisone,	Yes	1st degree AVB	7	No
2	Methimazole	Atropine	Yes	1st degree AVB	8	No
3	Propylthiouracil, iodine-131	Atropine, isoprenaline	No	Returned to normal	-	No
4	Methimazole	Prednisolone	Yes	Returned to normal	1	No
5	-	-	-	Returned to normal	-	-
6	Carbimazole, intravenous iodide a	Dexamethasone	No	Returned to normal	-	No
7	Methimazole	-	No	No recovery	No recovery	Yes
8	-	Prednisone	No	No recovery	No recovery	Yes
9	Propylthiouracil	-	No	1st degree AVB	-	No
10	Propylthiouracil	-	No	Returned to normal	-	No
11	Methimazole	Atropine	Yes	No recovery	No recovery	Yes
12	Propylthiouracil	-	No	Returned to normal	3	No
13	Carbimazole	-	Yes	Returned to normal	21	No
14	Propylthiouracil	-	No	Returned to normal	8	No
15	Propylthiouracil, subtotal thyroidectomy	-	No	Returned to normal	7	No
16	Propylthiouracil	Steroid	No	1st degree AVB	7	No
17	Radioactive iodine	-	No	Returned to normal	-	No
18	-	-	No	Returned to normal	-	No
19	-	-	No	Returned to normal	2	No
20	Carbimazole	-	No	1st degree AVB	2	No
21	Propylthiouracil	-	Yes	Normal	8	No
22	Carbimazole	Atropine	Yes	Sinus bradycardia	2	No
23	-	-	No	Returned to normal	-	No
24	Carbimazole	Atropine	Yes	Returned to normal	4	No
25	Propylthiouracil and potassium iodine	-	No	Returned to normal	10	No
26	Methylmercaptoimidazole	Atropine	Yes	Returned to normal	2	No
27	Subtotal thyroidectomy	-	No	Returned to normal	-	No
28	Carbimazole	-	No	Returned to normal	2	No
29	Methimazole, surgical treatment	-	No	Returned to normal	-	No
30	Methimazole	-	No	No recovery	No recovery	Yes
31	Methimazole	-	No	Arrhythmias were fewer and shorter	-	No
32	Propylthiouracil	-	Yes	No recovery	No recovery	Yes
33	Methimazole	-	Yes	No recovery	No recovery	Yes
34	Propylthiouracil	-	No	/	/	Yes

¹Treatment included drugs or temporary pacemaker. -: Information not available; /: Did not occur. AVB: Atrioventricular block; ECG: Electrocardiogram.