Difficulties in diagnosing angiomatoid fibrous histiocytoma of the head and neck region: A case report

Table 2 Variant with potential therapeutic relevance of gene MRE11

Item	Description
Gene	MRE11 (germline)
Functional category	Splice_region
Variant	c.1867+5G > T;P.?
NAF in germline	0.52
Effect on protein function	Probably inactivating
Therapeutic option for discussion in the MTB	PARP inhibitor
Approved by EMA/FDA	EMA & FDA
Approved for current entity	Po

PARP inhibitor: Inhibitor of the enzyme poly ADP ribose polymerase. MTB: Molecular Tumor Boards; EMA: European Medicines Agency; FDA: Food and Drug Administraction.