Clinical study of extrahepatic biliary adenoma

Table 1 Cases of extrahepatic biliary adenoma including their clinical presentation, histology and treatment

Patient	Male/female	Age, yr	Location	Presentation	Preoperative diagnosis	Treatment	Size (cm)/number of tumors	Histology	Outcome
1	Male	87	Distal CBD	Chills, fever	Choledocholithiasis	Local excision and T-tube drainage	0.6 cm × 0.5 cm/1	Papillary adenoma	Well at 2 yr after surgery
2	Male	78	Distal CBD	Painless jaundice	Distal cholangiocarcinoma	Pancreaticoduodenectomy	1.2 cm × 1 cm/1	Papillary adenoma	Well at 7 mo after surgery
3	Female	58	Common hepatic duct, right and left intrahepatic ducts	Abdominal pain, jaundice, dark urine	Multiple hepatic exterior and interior calculus of bile duct	Local lesion biopsy and T-tube drainage	2 cm × 0.8 cm (biggest)/several	Papillary adenoma (biliary papillomatosis)	8 mo after surgery, jaundice, ERCP + plastic biliary stent
4	Female	46	Common hepatic duct	Abdominal pain, jaundice	Hilar cholangiocarcinoma	Local excision, Roux-en-Y hepatojejunostomy	1 cm × 0.8 cm/1	Tubulovillous adenoma	Well at 3 yr after surgery
5	Male	60	Distal CBD	Abdominal pain and distention	Distal cholangiocarcinoma	Pancreaticoduodenectomy	1 cm × 1 cm/1	Tubular adenoma	Well at 6 yr after surgery
6	Female	64	Distal CBD	Abdominal pain, fever, nausea and vomiting	Common bile duct neoplasms	Local excision, Roux-en-Y hepatojejunostomy	1 cm × 1.2 cm/1	Tubular adenoma	Well at 6 yr after surgery
7	Female	82	Distal CBD	Abdominal pain, fever, nausea and vomiting	Choledocholithiasis	Local excision and T-tube drainage	0.9 cm × 0.7 cm/1	Tubular adenoma	Died after 2 mo due to heart failure
8	Female	49	Distal CBD	Painless jaundice	Distal cholangiocarcinoma	Pancreaticoduodenectomy	2 cm × 2 cm/1	Tubulovillous adenoma	Well at 4 yr after surgery
9	Female	62	Left hepatic and common hepatic ducts	Abdominal pain, and fever	Hilar cholangiocarcinoma	Local excision, Roux-en-Y hepatojejunostomy	3 cm × 2 cm/1	Tubular adenoma	Well at 5 yr after surgery

CBD: Common bile duct; ERCP: Endoscopic retrograde cholangiopancreatography.