Reduction rate of monoclonal protein as a useful prognostic factor in standard-risk group of newly diagnosed multiple myeloma

Table 4 Multivariate analysis of overall survival

Prognostic factor	HR (95%CI)	P value
ISS stage	1.879 (1.315-2.686)	0.001
Age	1.054 (1.027-1.081)	0.024
DS stage	1.829 (0.791-4.233)	0.158
GOT	1.009 (0.988-1.031)	0.395
LDH	0.998 (0.996-1.001)	0.264
Platelet count	2.929 (1.269-6.756)	0.012
Autotransplantation	0.211 (0.069-0.647)	0.006
TC	0.735 (0.573-0.943)	0.016
C1 reduction rate	0.868 (0.543-1.387)	0.553
C2 reduction rate	0.680 (0.386-1.197)	0.181
C3 reduction rate	1.055 (0.592-1.879)	0.856
C4 reduction rate	0.608 (0.350-1.058)

HR: Hazard ratio; 95%CI: 95% confidence interval; ISS: International Staging System; DS: Durie-Salmon; GOT: Glutamic-oxaloacetic transaminase; LDH: Lactate dehydrogenase; TC: Total cholesterol; C1: The first cycle; C2: The second cycle; C3: The third cycle; C4: The fourth cycle.