Reduction rate of monoclonal protein as a useful prognostic factor in standard-risk group of newly diagnosed multiple myeloma

Table 3 Multivariate analysis of progression-free survival

Prognostic factor	HR (95%CI)	P value
Age	1.059 (1.033-1.085)	≤ 0.001
ISS stage	2.136 (1.500-3.041)	≤ 0.001
DS stage	1.622 (0.264-1.622)	0.264
GPT	1.017 (0.997-1.036)	0.097
GOT	1.002 (0.977-1.028)	0.857
LDH	1.000 (0.997-1.003)	0.944
Platelet count	1.880 (0.732-4.830)	0.189
Maintenance regimen	0.410 (0.236-0.710)	0.001
Autotransplantation	0.201 (0.069-0.583)	0.003
TC	0.689 (0.533-0.891)	0.005
C1 reduction rate	0.474 (0.293-0.767)	0.002
C2 reduction rate	0.792 (0.440-1.427)	0.438
C3 reduction rate	1.974 (0.921-4.230)	0.08
C4 reduction rate	0.254 (0.139-0.463)	≤ 0.001

HR: Hazard ratio; 95%CI: 95% confidence interval; ISS: International Staging System; DS: Durie-Salmon; GPT: Glutamic-pyruvic transaminase; GOT: Glutamic-oxaloacetic transaminase; LDH: Lactate dehydrogenase; TC: Total cholesterol; C1: The first cycle; C2: The second cycle; C3: The third cycle; C4: The fourth cycle.