Anti-bacterial mechanism of baicalin-tobramycin combination on carbapenem-resistant Pseudomonas aeruginosa

Table 2 Differences in relative expression levels between related genes

Index	Group	Assay name	∆Ct	∆∆CT	Fold change	Up/down
1	Baicalin	VIM	15.94	2.63	0.16	Down
	Tobramycin	VIM	16.81	3.50	0.09	Down
	Baicalin + tobramycin	VIM	18.09	4.78	0.04	Down
	Control	VIM	13.31		1.00
2	Baicalin	IMP	13.73	2.58	0.17	Down
	Tobramycin	IMP	13.49	2.34	0.20	Down
	baicalin+ tobramycin	IMP	13.56	2.41	0.19	Down
	Control	IMP	11.15		1.00
3	Baicalin	OprD2	10.13	-0.11	1.08	Up
	Tobramycin	OprD2	11.40	1.16	0.45	Down
	Baicalin + tobramycin	OprD2	9.64	-0.60	1.52	Up
	Control	OprD2	10.24		1.00
4	Baicalin	algD	1.88	0.37	0.77	Down
	Tobramycin	algD	2.23	0.72	0.61	Down
	Baicalin + tobramycin	algD	3.44	1.93	0.26	Down
	Control	algD	1.51		1.00
5	Baicalin	pslA	3.29	0.63	0.65	Down
	Tobramycin	pslA	3.11	0.45	0.73	Down
	Baicalin + tobramycin	pslA	3.17	0.51	0.70	Down
	Control	pslA	2.66		1.00
6	Baicalin	lasR	1.18	-0.09	1.06	Up
	Tobramycin	lasR	1.43	0.16	0.90	Down
	Baicalin + tobramycin	lasR	1.66	0.39	0.76	Down
	Control	lasR	1.27