Intestinal complications in patients with Crohn’s disease in the Brazilian public healthcare system between 2011 and 2020

Table 2 Incidence rate of intestinal complications (combined and segregated by type of intestinal complications) in general population with Crohn’s disease (n = 16809), patients with no evidence of anti-tumor necrosis factor therapy (conventional therapy-only, n = 12163), and patients with evidence of anti-tumor necrosis factor therapy (n = 4646)

	Total number of events	First event1 (n)	PY	IR per 100 PY (95%CI)
General patients with CD (n = 16809)
Overall (combined)	14697	4633	61931.84	7.48 (7.27–7.68)
Associated disease	9429	4162	63123.61	6.59 (6.39–6.78)
Procedure-related	4707	2706	67528.54	4.00 (3.85–4.15)
CD hospitalization-related	561	454	73645.51	0.61 (0.55–0.67)
CVT-only (n = 12163)
Overall	6415	3026	44431.39	6.8105 (6.5763–7.0447)
Associated disease	5890	2739	45060.27	6.0785 (5.8579–6.2991)
Procedure-related	2934	1768	47820.30	3.6972 (3.5281–3.8663)
CD-related hospitalization	286	247	51654.41	0.5782 (0.4187–0.5377)
Evidence of anti-TNF therapy (4646)
Overall	3928	1607	17500.45	9.1826 (8.7548–9.6105)
Associated disease	3539	1423	18063.34	7.8778 (7.485–8.2707)
Procedure-related	1773	938	19708.24	4.7594 (4.4622–5.0567)
CD hospitalization-related	275	207	21991.1	0.9413 (0.8137–1.0689)

¹Counted only the first intestinal complication (number of patients), but patients could present more than one intestinal complication or type of intestinal complications.

PY: Patient year [sum time of all patients under risk – since index date up to date of first intestinal complications (IC, patients with ICs) or date of last available data (patients without ICs)]. Prior to anti-tumor necrosis factor (anti-TNF) therapy: Since index date up to date of first IC or up to date of anti-TNF therapy initiation. After anti-TNF therapy: Since date of anti-TNF therapy initiation up to date of first IC or up to date of last available data (without ICs). Associated disease according to ICD-10 code: International Classification Disease - 10^th edition. CD: Crohn’s disease; CVT: Conventional therapy; ICs: intestinal complications; IR: Incidence rate = n of patients with event/PY × 100; TNF: Tumor necrosis factor.