Prognostic factors for disease-free survival in postoperative patients with hepatocellular carcinoma and construction of a nomogram model

Table 2 Univariate analysis of different factors associated with disease-free survival in hepatocellular carcinoma patients

Characteristics	HR value (95%CI)	P value
Gender
Male	1.00 (reference)
Female	0.840 (0.574, 1.230)	0.371
Age (yr)
< 70	1.00 (reference)
≥ 70	0.577 (0.350, 0.951)	0.031a
Smoking history
No	1.00 (reference)
Yes	1.031 (0.770, 1.381)	0.839
Alcohol use history
No	1.00 (reference)
Yes	0.813 (0.601, 1.101)	0.182
History of hepatitis B
No	1.00 (reference)
Yes	1.392 (1.008, 1.921)	0.044a
Hypertension
Yes	1.00 (reference)
No	0.684 (0.471, 0.993)	0.046a
Diabetes
No	1.00 (reference)
Yes	0.816 (0.513, 1.298)	0.390
BMI
≥ 23	1.00 (reference)
< 23	0.912 (0.682, 1.221)	0.537
Liver cirrhosis
No	1.00 (reference)
Yes	1.321 (0.930, 1.876)	0.120
Ascites
No	1.00 (reference)
Yes	1.172 (0.774, 1.776)	0.453
Cancer nodules
Single	1.00 (reference)
Multiple	1.668 (1.140, 2.497)	0.013a
Capsule
No	1.00 (reference)
Yes	1.349 (0.925, 1.966)	0.120
Tumor diameter (cm)
< 5	1.00 (reference)
≥ 5	1.350 (1.010, 1.804)	0.043a
Differentiation grade		0.124
Moderate and High	1.00 (reference)
Low	1.291 (0.932, 1.787)	0.124
TNM stage
I-II	1.00 (reference)
III-IV	1.692 (1.224, 2.340)	0.001a
Portal vein thrombus
No	1.00 (reference)
Yes	2.862 (1.508, 5.432)	0.001a
HBsAg
Negative	1.00 (reference)
Positive	1.107 (0.774, 1.582)	0.579
AFP (ng/mL)
≥ 400	1.00 (reference)
< 400	0.958 (0.683, 1.345)	0.805
Fibrinogen (g/L)
≤ 4	1.00 (reference)
> 4	1.494 (1.037, 2.152)	0.031a
Prothrombin time
Abnormal	1.00 (reference)
Normal	0.836 (0.565, 1.236)	0.369
ALB (g/L)
< 40	1.00 (reference)
≥ 40	0.988 (0.746, 1.335)	0.457
TBIL (μmol/L)
≤ 20.5	1.00 (reference)
> 20.5	1.180 (0.762, 1.827)	0.457
TC (mmol/L)
≤ 5.2	1.00 (reference)
> 5.2	1.401 (0.980, 2.003)	0.065
ALT (U/L)
≤ 50	1.00 (reference)
> 50	1.049 (0.743, 1.481)	0.786
AST (U/L)
≤ 40	1.00 (reference)
> 40	1.055 (0.785, 1.416)	0.724
GTT (U/L)
≤ 60	1.00 (reference)
> 60	1.279 (0.957, 1.709)	0.097
NLR		0.938
< 2.19	1.00 (reference)
≥ 2.19	0.988 (0.740, 1.321)	0.938
PLR
< 97.67	1.00 (reference)
≥ 97.67	0.956 (0.715, 1.277)	0.759

^aP < 0.05.

BMI: Body mass index; TNM: Tumor node metastasis; HBsAg: Hepatitis B surface antigen; AFP: Alpha-fetoprotein; ALB: Albumin-bilirubin; TBIL: Total bilirubin; TC: Total cholesterol; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; GGT: Gamma-glutamyl transpeptidase; NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio.