Evaluating tumor-infiltrating lymphocytes in hepatocellular carcinoma using hematoxylin and eosin-stained tumor sections

Table 1 Clinicopathological data of the patients

Variable		No. of case
Age (median)		56 (204)
Gender	Male	174
	Female	30
HBV infection	Yes	187
	No	12
	Not mentioned	5
HBV DNA	Positive	66
	Negative	108
	Not mentioned	30
MaVI	Yes	21
	No	183
MVI	Positive	110
	Negative	94
Differentiation	Moderately differentiated	73
	Poorly differentiated	131
Histological subtype	Microtrabecular/pseudoglandular	87
	Macrotrabecular	108
	compact	5
	Lymphoepithelioma-like	4
Tumor number	Single	156
	Multiple (≥ 2)	48
Largest tumor diameter	≤ 10 cm	189
	> 10 cm	15
Capsule	Yes	117
	No	87
Cirrhosis in peritumor	Yes	171
	No	33
TILsCT	≤ 30	35
	> 30	169
TILsIF	≤ 200	62
	> 200	140
PILs	≤ 200	113
	> 200	89

MaVI: Macrovascular invasion; MVI: Microvascular invasion; TILs^CT: Tumor infiltrating lymphocytes in the tumor center; TILs^IF: Tumor infiltrating lymphocytes in the invasive front 1 mm spacing from the malignant nests, two cases cannot assess infiltrating lymphocytes in the invasive front; PILs: Infiltrating lymphocytes in the peritumor, two cases cannot assess infiltrating lymphocytes in peritumor areas; HBV: Hepatitis B virus.